Kilmax® 125 Tablet: Each film-coated tablet contains amorphous Cefuroxime Axetil USP equivalent to Cefuroxime 125 mg.
Kilmax® 250 Tablet : Each film-coated tablet contains amorphous Cefuroxime Axetil USP equivalent to Cefuroxime 250 mg.
Kilmax® 500 Tablet: Each film-coated tablet contains amorphous Cefuroxime Axetil USP equivalent to Cefuroxime 500 mg.
Kilmax® Powder for Suspension: Each 5 ml suspension contains amorphous Cefuroxime Axetil USP equivalent to Cefuroxime 125 mg.
Kilmax® 750 IV Injection: Each vial contains 750 mg Cefuroxime as sterile Cefuroxime Sodium USP and one ampoule of 10 ml sterile water for Injection USP.
Kilmax® 1.5 g IV Injection: Each vial contains 1.5 g Cefuroxime as sterile Cefuroxime Sodium USP and two ampoules of 10 ml sterile water for Injection USP.
Kilmax® is a product of the bactericidal cephalosporin antibiotic Cefuroxime, which is resistant to most beta-lactamases and is active against a wide range of gram-positive and gram-negative organisms. The bactericidal action of Cefuroxime results from inhibition of cell-wall synthesis by binding to essential target proteins.
Oral:
Parenteral:
General doses and recommendation:
Adults: Many infections respond to 750 mg three times daily by IV injection. For more severe infections the dose should be increased to 1.5 g IV three times daily. The frequency of administration may be increased to 6 hourly if necessary, giving total daily doses of 3 to 6 g.
Infants and Children: 30 - 100 mg/kg/day given as 3 or 4 divided doses. A dose of 60 mg/kg/day is appropriate for most infections.
Neonates: 30 - 100 mg/kg/day given as 2 or 3 divided doses.
Other recommendation:
Meningitis: Cefuroxime sodium for injection is suitable for sole therapy of bacterial meningitis due to sensitive strains.
Adults: 3 g IV every eight hours.
Infants and Children: 150-250 mg/kg/day IV in 3 or 4 divided doses.
Neonates: The dosage should be 100 mg/kg/day IV.
Surgical Prophylaxis: The usual dose is 1.5 g of Cefuroxime intravenously before the procedure.
In bone and joint infections, a 1.5 g dose every 8 hours is recommended.
Sequential therapy: Pneumonia:
1.5 g three times daily or twice daily (given intravenously) for 48-72 hours, followed by 500 mg twice daily oral therapy for 7-10 days.
Acute exacerbations of chronic bronchitis:
750 mg three times daily or twice daily (given intravenously) fo - o - s. Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.
In impaired renal function:
Cefuroxime Sodium for injection should be reduced in renal impairment. It is not necessary to reduce the standard dose (750 mg - 1.5 g three times daily) until the creatinine clearance falls to 20 mL/min or below. In adults with marked impairment (creatinine clearance 10- 20 mL/min) 750 mg twice daily is recommended and with severe impairment (creatinine clearance < 10 mL/min) 750 mg once daily is adequate. For patients on haemodialysis a further 750 mg dose should be given IV at the end of each dialysis. In addition to parenteral use, Cefuroxime can be incorporated into the peritoneal dialysis fluid.
Direction for Reconstitution:
Kilmax®750 IV Injection:
Add 8 ml sterile water for Injection to the vial and shake vigorously. The solution slowly injected directly into a vein over a 3 to 5 minutes period.
Kilmax®1.5 g IV Injection:
Add 16 ml sterile water for Injection to the vial and shake vigorously. The solution slowly injected directly into a vein over a 3 to 5 minutes period.
There is no experimental evidence of embryopathic or teratogenic effects attributable to Cefuroxime but as with all drugs, it should be administered with caution during early months of pregnancy. Cefuroxime is excreted in human milk and consequently caution should be exercised when Cefuroxime is administered to a nursing mother.
Store in a cool (below 30°C) and dry place, keep away from light. Keep out of the reach of children. In case of injection, use freshly prepared solution. Reconstituted solution is stable for 2 hours at room temperature and for 24 hours in a refrigerator at 2°C to 8°C.