Cefotil™ Plus 250 Tablet: Each tablet contains Cefuroxime 250 mg as Cefuroxime Axetil BP 300.70 mg and Clavulanic Acid 62.50 mg as Diluted Potassium Clavulanate BP 125 mg.
Cefotil™ Plus 500 Tablet: Each tablet contains Cefuroxime 500 mg as Cefuroxime Axetil BP 601.40 mg and Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP 250 mg.
Cefotil™ Plus Powder for Suspension (70 ml): Each 5 ml reconstituted suspension contains Cefuroxime 125 mg as Cefuroxime Axetil BP and Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate BP.
Cefuroxime is a broad spectrum second generation Cephalosporin active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. The bactericidal action of Cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins. Cefuroxime has good stability to bacterial beta-lactamases.
Clavulanic Acid has a similar structure to the beta-lactam antibiotics but binds irreversibly to the beta-lactamase enzymes. The presence of Clavulanic Acid protects Cefuroxime from degradation by beta-lactamase enzymes and effectively extends the antibacterial spectrum of Cefuroxime to include many bacteria normally resistant to Cefuroxime and other Cephalosporins.
Adults (13 years and older):
Infection.
Dosage:
Duration (days).
Pharyngitis/Tonsillitis.
250 mg b.i.d.
5-10.
Acute Bacterial Maxillary Sinusitis.
250 mg b.i.d.
10.
Acute Bacterial Exacerbations of Chronic Bronchitis.
250 - 500 mg b.i.d.
10.
Secondary Bacterial Infections of Acute Bronchitis.
250 - 500 mg b.i.d.
5-10.
Uncomplicated Skin and Skin-Structure Infections.
250 - 500 mg b.i.d.
10.
Community Acquired Pneumonia.
250 - 500 mg b.i.d.
5-10.
MDR Typhoid Fever.
500 mg b.i.d.
10-14.
Uncomplicated Urinary Tract Infections.
250 mg b.i.d.
7-10.
Uncomplicated Gonorrhea.
1,000 mg single dose.
-.
Lyme Disease.
500 mg b.i.d.
20.
Pediatric Patients (03 months to 12 years, who can swallow tablet whole):
Infection.
Dosage:
Duration (days).
Acute Otitis Media.
250 mg b.i.d.
10.
Acute Bacterial Maxillary Sinusitis.
250 mg b.i.d.
10.
Cefuroxime-Clavulanic Acid tablet may be taken without regard of food.
Pediatric Patients (03 months to 12 years): Must be administered with food. Shake well each time before using.
Infection.
Dosage:
Daily maximum dose.
Duration (days).