Famiclavâ„¢ 250 Tablet: Each film-coated tablet contains Cefuroxime 250 mg as Cefuroxime Axetil USP and Clavulanic Acid 62.50 mg as diluted Potassium Clavulanate BP.
Famiclavâ„¢ 500 Tablet: Each film-coated tablet contains Cefuroxime 500 mg as Cefuroxime Axetil USP and Clavulanic Acid 125 mg as diluted Potassium Clavulanate BP.
Famiclavâ„¢ Powder for Suspension: After reconstitution, each 5 ml suspension contains Cefuroxime 125 mg as Cefuroxime Axetil USP and Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate BP.
Cefuroxime is a well-characterized and effective antibacterial agent, which has broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains. Cefuroxime has good stability to bacterial β-lactamase and consequently, is active against many Ampicillin-resistant and Amoxicillin-resistant strains. Clavulanic Acid has a similar structure to the beta-lactam antibiotics but binds irreversibly to the beta-lactamase enzymes. The presence of Clavulanic Acid in Famiclav™ formulations protects Cefuroxime from degradation by β-lactamase enzymes and effectively extends the antibacterial spectrum of Cefuroxime to include many bacteria normally resistant to Cefuroxime and other Cephalosporins.
Infection.
Dosage:
Duration.
Adolescents and Adults (13 years and older):
Pharyngitis/ tonsillitis.
250 mg b.i.d.
10 days.
Acute bacterial maxillary sinusitis.
250 mg b.i.d.
10 days.
Acute bacterial exacerbations of chronic bronchitis.
250 or 500 mg b.i.d.
10 days.
Secondary bacterial infections of acute bronchitis.
250 or 500 mg b.i.d.
5-10 days.
Uncomplicated skin and skin-structure infections.
250 or 500 mg b.i.d.
10 days.
Uncomplicated urinary tract infections.
125 or 250 mg b.i.d.
7-10 days.
Uncomplicated gonorrhoea.
1,000 mg once.
Single dose.
Early Lyme Disease.
500 mg b.i.d.
20 days.
Pediatric Patients (who can swallow tablets whole):
Acute otitis media.
250 mg b.i.d.
10 days.
Acute bacterial maxillary sinusitis.
250 mg b.i.d.
10 days.
Infection.
Dosage:
Daily Maximum Dose.
Duration.
Pediatric Patients (3 months to 12 years):
Pharyngitis /tonsillitis.
20 mg/kg/day divided b.i.d.
500 mg.
10 days.
Acute otitis media.
30 mg/kg/day divided b.i.d.
1,000 mg.
10 days.
Acute bacterial maxillary sinusitis.
30 mg/kg/day divided b.i.d.
1,000 mg.
10 days.
Impetigo.
30 mg/kg/day divided b.i.d.
1,000 mg.
10 days.
Or as Directed by the Physician.:Directions for reconstitution for oral suspension:
Volume of water required for reconstitution for labeled volume of suspension:
Suspension.
Labeled volume after reconstitution.
Volume of water required for reconstitution.
125 mg & 31.25 mg / 5 ml.
70 ml.
35 ml.
Water used for reconstitution should be boiled and cooled. The reconstituted suspension must be stored at 2°-8°C temperature & should be used within 7 days after reconstitution.
Famiclavâ„¢ should be given with care to patients receiving concurrent treatment with potent diuretics & who have history of colitis.