Alaclov 10 tablet: Each tablet contains Valaciclovir 500 mg.
Alaclov is a preparation of Valaciclovir which is an antiviral agent. It is a prodrug, converted by esterases to the active drug Aciclovir, as well as the amino acid valine, via hepatic firstpass metabolism.
Route: Oral
Adults:
Pediatric:
Renal impairment (Adult Herpes Zoster):
Probenecid and cimetidine decrease renal clearance of acyclovir, increasing serum concentrations; concomitant nephrotoxic drugs (aminoglycosides, cyclosporine, tacrolimus) increase risk of renal dysfunction.
Valaciclovir is contraindicated in patients with clinically significant hypersensitivity reaction to Valaciclovir, Aciclovir, or any component of the formulation.
Common: Nausea, vomiting, fatigue, headache, dizziness, abdominal pain, fever. Less Common: Agitation, confusion, speech difficulties, unsteady movement, vision changes. Rare: Hallucinations, seizures, loss of consciousness.
Overdose
Acute renal failure & neurological symptoms, including confusion, hallucinations, agitation, decreased consciousness & coma, have been reported in patients receiving overdoses of Valaciclovir. Caution is required to prevent inadvertent overdosing. Haemodialysis significantly enhances the removal of Aciclovir from the blood and may, therefore, be considered a management option in the event of symptomatic overdose.
Category B. Clinical registries have not shown increased birth defects; use during pregnancy only if potential benefit justifies fetal risk. Lactation: Excreted into breast milk as acyclovir; caution advised.
Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.