Cazep 200 mg Tablet: Each tablet contains Carbamazepine BP 200 mg.
Carbamazepine (Cazep ) is an iminodibenzyl derivative with anticonvulsant properties and its structure is related to the tricyclic antidepressants.
Mode of action:
Carbamazepine (Cazep ) has a wide range of pharmacological effects in animals and humans. The anticonvulsant effects of Carbamazepine are more pronounced against electroshock seizures than against chemically induced seizures. Carbamazepine reduces the generation of high frequency repetitive firing by blocking sodium channels in a use and frequency-dependant manner. This is thought to be its main mode of action, although it also reduces sodium and calcium flux through N-methyl-D-asparate (NMDA)-activated channels at glutamate receptor sites. In addition, it blocks the reuptake of norepinephrine into presynaptic terminals and has adenosine receptor antagonistic effects.
Pharmacokinetics:
The gastrointestinal absorption of Carbamazepine (Cazep ) in humans has been estimated at between 72% and 96% with peak plasma concentrations occurring between 6 and 24h. Carbamazepine is lipophilic and once in the circulation it rapidly penetrates through cell membranes to gain access to various body tissues. The concentration of Carbamazepine in brain is similar to that found in plasma. Carbamazeine is about 54%-80% bound to plasma protein. The plasma half-life following a single dose is 30-40 hrs whereas on multiple dosing it is 11.7 hr. Carbamazepine is extensively metabolized in the liver with only about 1% of the administered dose excreted in urine in the unchanged form.
Epilepsy (All forms of epilepsy except myoclonic and absence seizures), trigeminal neuralgia, mood disorder, aggression and diabetic insipidus.
In epilepsy : adults : The initial dose of Carbamazepine is 100-200 mg once or twice daily and this is then gradually increased by 200 mg daily every week until seizure control or therapeutic plasma concentration is achieved. in children : The dose in children is determined on the basis of body weight (10-20 mg/kg) and age, children 0 to 1 year old : 100-200 mg daily; 1 to 5 years : 200-400 mg daily; 6 to 10 years old : 400-600 mg daily; 11 to 15 years old : 600-1000 mg daily. In trigeminal neuralgia, the initial dose is usually 200 mg daily and may be slowly increased until attacks of pain are prevented. In some instances a dose of 1600 mg daily is necessary. In the acute treatment of mania and the prophylaxis of bipolar mood disorders, the usual effective dose range is 400-600 mg daily. For diabetic insipidus : The average dose for adult patients is 200 mg Carbamazepine given two to three times daily. In children the dose should be determined according to body weight (10-20 mg/Kg).
Women using oral contraceptive pills may become pregnant during therapy with Carbamazepine. Carbamazepine, like any other psychoactive drug may reduce the patient s tolerance to alcohol. Carbamazepine has been observed to shorten the half-life of doxycycline. Clarithromycin, erythromycin, INH, and fluoxetine increase plasma concentration of Carbmazepine.
Plasma concentration of Carbamazeine decreases during pregnancy. Therefore increased dose of carbamezepine is suggesting during pregnancy. Beast feeding is not contraindicated. This drug should be used in pregnancy and lactation if absolutely needed.
Cardiovascular disease, hepatic or renal disorders, changing treatment from Carbamazepine to another antiepileptic drug, hematological disorders and glaucoma.
Store in a cool (Below 25 C temperature) and dry place protected from light.