Apresin® Tablet: Each tablet contains Fluphenazine Hydrochloride BP 0.5 mg and Nortriptyline 10 mg as Nortriptyline Hydrochloride BP.
Apresin is a preparation of Fluphenazine Hydrochloride BP and Nortriptyline Hydrochloride BP. Fluphenazine is a tranquilizer of the phenothiazine type. Nortriptyline is a tricyclic antidepressant having less sedative action. This combination has been found as an effective preparation for the patients suffering from "anxiety" or "depression" or both and helps to restore functional ability without developing any drug dependence.
Adults: One Apresin tablet 2 to 3 times daily.
Interactions with barbiturates, alcohol, and narcotic drugs may occur, so central depressants should be administered with caution.
Tardive dyskinesias have been reported in phenothiazine therapy; usually after prolonged courses given at doses adequately to control psychotic illness. Blood dyscrasia, Malignant Neuroleptic syndrome and sudden death have been reported rarely. Agranulocytosis is a rare but potentially fatal adverse effect of Nortriptyline Hydrochloride.
The safety in human pregnancy has not been yet established. The use of this drug in lactation is not recommended, as it is excreted in breast milk.
Precautions should be taken in patients with glaucoma, prostate enlargement, cardiac failure and myocardial infarction, and in concurrent administration with CNS depressants. The drug may impair alertness and abilities to drive a car or operate machinery.
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THERAPEUTIC INDEX