Virux® Cream: Each gram cream contains Aciclovir BP 50 mg.
Aciclovir is a synthetic purine derivative. It exerts its antiviral effect on *Herpes simplex* virus (HSV) and *Varicella zoster* virus by interfering with DNA synthesis and inhibiting viral replication. In cells infected with herpes virus, the antiviral activity of Aciclovir appears to depend principally on the intracellular conversion of the drug to Aciclovir Triphosphate. Aciclovir is converted to Aciclovir Monophosphate principally via virus coded thymidine kinase; the monophosphate is phosphorylated to the diphosphate via cellular guanylate kinase and then via other cellular enzyme to the triphosphate, which is the pharmacologically active form of the drug. Percutaneous absorption of Aciclovir appears to be minimal following topical application of the drug to intact skin.
Virux® Cream is indicated for the treatment of initial and recurrent labial and genital *Herpes simplex* infections. Treatment should begin as early as possible.
Virux® Cream should be applied to lesions 5 times daily for 5-10 days. The affected area should be kept clean and dry; patients should be instructed to wear loose-fitting clothing to avoid irritation to the lesion.
Probenecid reduces Acyclovir excretion and so increases plasma concentration and risk of toxicity.
Pregnancy Category B: Aciclovir should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. Caution should be exercised when it is administered to a nursing mother.
Virux® Cream is not recommended for application to buccal or vaginal mucous membrane. Care should be taken to avoid accidental introduction into the eye.
Store below 25°C. Protected from light. Keep out of the reach of children.