Zox® tablet: Each film coated tablet contains Nitazoxanide INN 500 mg.
Zox® 30 ml suspension: Each 5 ml suspension contains Nitazoxanide INN 100 mg.
Nitazoxanide, a synthetic antiprotozoal agent. Nitazoxanide is well absorbed from GIT. It interferes with the Pyruvate Ferredoxin Oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic glucose energy metabolism. This results in cell swelling, membrane damage resulting in dysfunction of the parasite.
The suspension or tablet should be taken with food.
Nitazoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering Nitazoxanide concurrently with other highly plasma-protein bound drugs.
Overdose Information on Nitazoxanide overdose is not available. Single oral doses up to 4000 mg Nitazoxanide have been administered to healthy adults without significant adverse effects.
Reconstitution for suspension Zox® 30 ml suspension: Shake the bottle well before adding water. Then add 20 ml of boiled and cooled water (with the help of provided cup) into the bottle and shake well to make 30 ml suspension.
Pregnancy Category B: This drug should be used during pregnancy only if clearly needed.
Nitazoxanide should be administrated with caution to patients with hepatic, renal and biliary disease.
Store below 30°C in a cool and dry place, protected from light & moisture. Once reconstituted suspension should be used within 7 days.