Each film coated tablet contains Amitriptyline 12.5 mg as Amitriptyline Hydrochloride USP and Chlordiazepoxide USP 5 mg.
Tryptin® Plus combines Amitriptyline, a tricyclic antidepressant and Chlordiazepoxide, an anxiolytic. Amitriptyline inhibits the reuptake of norepinephrine and serotonin in brain. This interference with the reuptake is responsible for antidepressant activity. Chlordiazepoxide, works by enhancing GABA-mediated chloride influx through GABA receptor channels, causes membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative and anxiolytic effect.
Tryptin® Plus is indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.
Tryptin® Plus tablet in an initial dosage of 3 or 4 tablets daily in divided doses is satisfactory.
The concomitant use of Benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration.
Use in special population:
Pregnancy & lactation: Safe use during pregnancy and lactation has not been established.
Pediatric use: Safety and effectiveness in the pediatric population have not been established. Anyone considering the use of Chlordiazepoxide and Amitriptyline in a child must balance the potential risks with the clinical need.
Use with caution in seizures & hyperthyroid patients. The continued use of Benzodiazepines may lead to clinically significant physical dependence. It also exposes users to risks of abuse, misuse and addiction.
Store below 30°C, protect from light and moisture. Keep medicine out of the reach of children.
Each box contains 30 tablets in blister pack.