Fodexil™ 500 Capsule: Each capsule contains Cefadroxil Monohydrate USP equivalent to 500 mg Cefadroxil.
Fodexil™ 1gm Tablet: Each tablet contains Cefadroxil Monohydrate USP equivalent to 1 gm Cefadroxil.
Cefadroxil is an acid-stable semi-synthetic oral antibiotic in Cephalosporin family. Cefadroxil acts by preventing bacteria from forming protective cell wall necessary for survival. It has superior pharmacokinetic profile over all first generation Cephalosporins.
Cefadroxil is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:
The bioavailability and consequent chemotherapeutic effects of Cefadroxil are unaffected by food. It may, therefore, be taken with meals or on an empty stomach. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral Cephalosporin therapy.
Indication:
Adult.
Children:
Upper Respiratory Tract Infections.
1 g/day in single or 2 divided doses for 10 days.
30 mg/kg/day in single or 2 divided doses for 10 days.
Uncomplicated Lower Urinary Tract Infections.
1-2 g daily as a single or 2 divided doses.
>6 years: 500 mg b.i.d.; 1-6 years: 250 mg b.i.d.; <1 year: 25 mg/kg daily in divided doses.
Skin & Soft Tissue Infections.
1 g/day in single or divided doses.
30 mg/kg/day in 2 equally divided doses.
Prothrombin time will be prolonged; bleeding may occur when taken with anticoagulants. Decreased elimination with Probenecid is also reported.
OVERDOSE Gastric lavage or vomiting is recommended for dose greater than 250 mg/kg.
Pregnancy Category B: But it should be used only if clearly needed. Caution should be exercised when Cefadroxil is administered to a nursing mother.
Cefadroxil should be used with caution in the presence of markedly impaired renal function (creatinine clearance rate of less than 50 ml/min.). For patients considering creatinine clearance <50 ml/min., starting dose 1000 mg and maintenance dose 500 mg should be administered as per following table:
Creatinine clearance (ml/min.).
Dosing interval.
1-10.
36 hr.
11-25.
24 hr.
26-50.
12 hr.
>50.
No need to adjust.
Cefadroxil can be excreted from body by hemodialysis. Prolonged use of Cefadroxil may result in the overgrowth of nonsusceptible organisms. Cefadroxil should be prescribed with caution in individuals with history of gastrointestinal disease, particularly colitis.
Store below 25° C, protected from light & moisture.