Salomax®Inhalation Capsules: Each capsule contains Salbutamol Sulfate BP equivalent to Salbutamol 200 mcg.
Salomax inhalation capsule is used for dry powder inhaler. It is intended for oral inhalation only. It contains Salbutamol (as Salbutamol Sulfate BP) as the active ingredient which is used in the treatment of bronchial asthma and reversible obstructive airway disease. Salbutamol is relatively selective B-2-adrenoreceptor stimulant.
PHARMACOLOGY Salbutamol sulfate is a agonist. The pharmacologic effects of Sulfate are attributable to activation of receptors on airway smooth muscle. Activation of receptors leads to the activation of adenylcyclase and to an increase in the intracellular concentration of cyclic-3',5 -adenosine monophosphate (cyclic AMP). This increase of cyclic AMP is associated with the activation of protein kinase A, which in turn inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in muscle relaxation.
Overdose:
The expected symptoms with overdosage are those of excessive β-adrenergic stimulation and/or occurrence or exaggeration of any of the symptoms listed under side effects, e.g., seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats per minute, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, and insomnia.
Hypokalemia may also occur. As with all sympathomimetic medications, cardiac arrest and even death may be associated with abuse of Salbutamol.
Treatment consists of discontinuation of Salbutamol together with appropriate symptomatic therapy. The judicious use of a cardio selective β-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm. There is insufficient evidence to determine if dialysis is beneficial for overdosage of Salbutamol.
Other short-acting sympathomimetic aerosol bronchodilators and adrenergic drugs: May potentiate effect. Beta-blockers: May decrease effectiveness of Salbutamol and produce severe bronchospasm. Patients with asthma should not normally be treated with beta-blockers. Diuretics, or non-potassium sparing diuretics: May potentiate hypokalemia or ECG changes. Consider monitoring potassium levels. Digoxin: May decrease serum digoxin levels. Consider monitoring digoxin levels. Monoamine oxidase (MAO) inhibitors and tricyclic antidepressants: May potentiate effect of Salbutamol on the cardiovascular system. Consider alternative therapy in patients taking MAOs or tricyclic antidepressants.
OVERDOSE he expected symptoms with overdosage are those of excessive B-adrenergic stimulation and/or occurrence or exaggeration of any of the symptoms listed under side effects, e.g., seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats per minute, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, and insomnia. Hypokalemia may also occur. As with all sympathomimetic medications, cardiac arrest and even death may be associated with abuse of Salbutamol. reatment consists of discontinuation of Salbutamol together with appropriate symptomatic therapy. The judicious use of a cardio selective B-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm. There is insufficient evidence to determine if dialysis is beneficial for overdosage of Salbutamol.
Although there is no evidence that salbutamol is teratogenic, it can be used in first trimester only if absolutely essential. It is pregnancy category C. Salbutamol probably enters breast milk, but the concentration is unknown.
However, no adverse effects have been reported in the breast-fed babies of months taking the drug by inhalation.
Please see opposite side of this leaflet.
Salomax®Inhalation capsules must not be swallowed. Only to be used with Turbohaler. Keep away from light and wet place.
Store at or below 25°C temperature. Keep out of reach of children. Remove Inhalation capsule from the blister pack only immediately before use it in the Turbohaler as Inhalation capsule exposed to moisture may not be pierced easily.
Method of Administration: