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Progavi®

Suspension

500 mg

GENERIC NAMESodium Alginate + Sodium Bicarbonate + Calcium Carbonate

MANUFACTURED BYBeximco Pharmaceuticals PLC

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Available Pack Sizes:1 Size

Maximum Retail Price (MRP):

Quantity

৳ 300.00/ 200 ml

16263

Composition

ProgaviÂ® Oral Suspension: Each 10 ml Suspension contains Sodium Alginate BP 500 mg, Sodium Bicarbonate BP 213 mg & Calcium Carbonate BP 325 mg.

Description

Progavi is the combination of two antacids (Calcium carbonate and Sodium bicarbonate) and an alginate (Sodium alginate).

The suspension work in two ways:

Neutralizing excess stomach acid to relieve the pain & discomfort.

Forming a protective barrier over the stomach contents to soothe the burning pain in your chest. On ingestion, Progavi reacts rapidly with gastric acid to form a raft of acidic acid gel having near neutral pH and studies have shown that the raft interacts with and caps the acid pocket in the stomach, reducing esophageal acid exposure. The raft floats on the stomach contents effectively impeding gastric-esophageal reflux or GERD, (or up to 4 hours), and protecting the esophagus from acid, pepsin and bile. In severe cases the raft itself may be refluxed into the esophagus, in preference to the stomach contents, and exert a demulcent effect. In addition, in vitro evidence has shown that the raft has a secondary action and is able to entrap bile & pepsin within the structure, further protecting the esophagus from these gastric components. The calcium, bicarbonate neutralizes gastric acid and to provide fast relief from indigestion and heartburn. This effect is increased by the addition of sodium bicarbonate which also has a neutralizing action. The total neutralizing capacity of the product at the lowest dose of 10 ml suspension is approximately 10.5 ml.

Indications

Treatment of symptoms resulting from the reflux of acid, bile and pepsin into the esophagus such as acid regurgitation, heartburn and indigestion, for example following meals or during pregnancy, and for symptoms of excess stomach acid (hyperacidity).

Dosage & Administration

Adults and children 12 years over: 10-20 ml after meals and at bed time, up to four times per day.

Children under 12 years: Should be given only on medical advice.

Elderly: No dose modifications necessary for this age group.

Interaction

Due to presence of calcium and carbonates which act as an antacid, a time-interval of 2 hours should be considered between intake of this product and the administration of other medicinal products, especially H2-antihistamines, tetracyclines, digoxine, fluoroquinolones, iron salts, thyroid hormones, ketoconazole, neuroleptics, thyroxine, penicillamine, beta-blockers (atenolol, metoprolol), propranolol, glucocorticoid, chloroquine, diphenylphosphonates and estramine.

Overdose

Symptoms: Symptoms are likely to be minor in acute overdose; some abdominal distension may be noticed. Milk alkali syndrome has occurred in individuals taking large doses of calcium carbonate per day for prolonged periods.

Contraindications

Hypernatremia, to sodium alginate, sodium bicarbonate, calcium carbonate, the esters of hydroxybenzenates (parabens) or to any of the excipients that used in suspension formulation. This product should not be used in patients with moderate or severe renal insufficiency.

Side Effects

Some common side effects are alkalosis, acid rebound, hypercalcaemia, milk-alkali syndrome & constipation which usually occurs following former the recommended dosages.

Use in Specific Populations**.

Pregnancy & Lactation

Based on clinical trial and previous experience ProgaviÂ® may be used during pregnancy, if clinically needed.

Breastfeeding: No effects of the active substance have been shown in breastfed newborns/ infants of treated mothers. This product can be used during breast-feeding if clinically needed.

Fertility: Clinical data do not suggest that this product has an effect on human fertility.

Precautions & Warnings

Each 20 ml of dose has a sodium content of 254.5 mg (11.06 mmol). This should be taken into account when a highly restricted salt diet is recommended, e.g., in some cases of congestive cardiac failure and renal impairment. * Each 20 ml contains 260 mg (6.5 mmol) of calcium. Care needs to be taken in treating patients with hypercalcaemia, nephrocalcaosis, and recurrent calcium containing renal calculi. * Treatment of children younger than 12 years of age is not generally recommended, except on medical advice.

Storage Conditions

Do not store above 30Â°C. Keep in a dry place. Protect from light and keep out of the reach of children.

In-use shelf life

Use ProgaviÂ® Oral Suspension within 30 days once the container is opened. Keep the container closed after each opening.

Progavi® • 200 ml

৳ 300.00