Tablet: Each film coated tablet contains Ibuprofen BP 400 mg.
Suspension: Each 5 ml suspension contains Ibuprofen BP 100 mg.
Profen (Ibuprofen) has a high level of anti-inflammatory, anti-pyretic and analgesic activity. The analgesic effects of Profen (Ibuprofen) are due to both a peripheral and a central effect. Profen (Ibuprofen) is a potent inhibitor of the enzyme cyclooxygenase, which thus results in a marked reduction in prostaglandin synthesis. Profen (Ibuprofen) also inhibits the synthesis of some lipo-oxygenase products. Profen (Ibuprofen) thus quickly relieves pain and stiffness, reduces swelling and improves the movement of different joints of arthritis sufferers.
Profen (Ibuprofen) is indicated in rheumatoid arthritis, osteoarthritis, gouty arthritis, juvenile polyarthritis, ankylosing spondylitis, synovitis, low back pain, dysmenorrhoea, fever, migraine, soft tissue injuries, pain and inflammation in dental and musculoskeletal origin.
Route of administration: Oral.
Adults: The dose is initially, 400 mg 3 times daily. A dose of 2400 mg daily should not be exceeded.
Children:
Not recommended for children weighing less than 5 kg. In juvenile rheumatoid arthritis; up to 30-40 mg/kg of body weight daily in 3-4 divided doses may be taken.
OR AS DIRECTED BY THE PHYSICIAN.
ACE inhibitors, Diuretics, Lithium, Anti-platelet agents, Warfarin, Aminoglycosides, Corticosteroids, Herbal Extracts, Cyclosporin, Tacrolimus, Mifepristone, Quinolone antibiotics, Zidovudine, Methotrexate, Voriconazole & Fluconazole.
Overdose:
Within one hour of ingestion of a potentially toxic amount of ibuprofen, use of activated charcoal should be considered. Alternatively in adults gastric lavage may be considered for potentially life-threatening overdoses.
Adverse effects of Ibuprofen on the developing fetus cannot be fully excluded. Ibuprofen should not be used during pregnancy and for nursing mothers unless the potential benefits to the mothers outweigh the potential risks.
The daily dosage of Ibuprofen is 20mg per kg of body weight in divided doses. In Juvenile Rheumatoid Arthritis up to 40mg/kg of body weight in divided doses may be given. In children weighing less than 30 kg the total dose should not exceed 500mg in a 24 hour period.
Ibuprofen should be used with caution and the lowest effective doses should be given if there is a history of gastrointestinal hemorrhage or ulcer. Patients on long term therapy with Ibuprofen require ocular monitoring at regular intervals, as changes in ocular function have been reported. Patients with systemic lupus erythematosus are more likely than others to develop hypersensitivity to Ibuprofen. Ibuprofen should be prescribed with caution in patients with asthma and in patients with a history of hypersensitivity to other nonsteroidal anti-inflammatory agents.
Store below 30°C temperature & in dry place, protected from light.
Keep out of the reach of children.