Zoxan® Tablet: Each film coated tablet contains Nitazoxanide INN 500 mg.
Zoxan® 30 ml Suspension: Each 5 ml reconstituted suspension contains Nitazoxanide INN 100 mg.
Zoxan® 60 ml Suspension: Each 5 ml reconstituted suspension contains Nitazoxanide INN 100 mg.
**Zoxan® is the preparation of nitazoxanide, a synthetic antiprotozoal agent.
Mode of action:
The antiprotozoal activity of nitazoxanide is believed to be due to interference with the pyruvate: ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. This results in membrane damage and ultimately dysfunction of the parasite.
Pharmacokinetics:
Nitazoxanide is well absorbed from GIT. After absorption it is converted to its active metabolite tizoxanide. In plasma, more than 99% of tizoxanide is bound to proteins. Following oral administration in humans, nitazoxanide is rapidly hydrolyzed to an active metabolite, tizoxanide (desacetyl-nitazoxanide). Tizoxanide then undergoes conjugation, primarily by glucuronidation. Tizoxanide is excreted in the urine, bile and feces, and tizoxanide glucuronide is excreted in urine and bile. Approximately two-thirds of the oral dose of nitazoxanide is excreted in the feces and one-third in the urine.
Although no drug-drug interaction studies have been conducted *in vivo*, it is expected that no significant interaction would occur when Nitazoxanide is co-administered with drugs that either are metabolized by or inhibit cytochrome P450 enzymes.
Over dosage:
Information on Nitazoxanide over dosage is not available. Single oral doses up to 4000 mg Nitazoxanide have been administered to healthy adults without significant adverse effects.
Pregnancy: This drug should be used during pregnancy only if clearly needed.
Nitazoxanide should be administered with caution to patients with hepatic, renal and biliary disease.
Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light. Once reconstituted suspension should be used within 7 days.