Nixcof® 100 ml Syrup: Each 5 ml contains Diphenhydramine Hydrochloride BP 14 mg, Guafenesin BP 100 mg & Levomenthol BP 1.10 mg.
Nixcof® is a combination of Diphenhydramine hydrochloride, Guafenesin & Levomenthol. This combination is used to get relief from cough and related congestive symptoms.
Mode of action Diphenhydramine is an antihistamine that helps relieve coughing, dry secretions in the nose and chest, and helps to sleep, guafenesin (an expectorant) to help loosen mucus (phlegm) from the lungs and make it easier to cough up, and levomenthol which helps to breathe more easily by relieving congestion.
Pharmacokinetics:
Absorption** Oral bioavailability of diphenhydramine hydrochloride is in the range of 40% to 60% and peak plasma concentration occurs about 2 to 3 hours after administration. Guafenesin is rapidly absorbed from the GI tract and absorption data of levomenthol is not found.
Distribution The oral availability of diphenhydramine is 61%, and 78% is bound in plasma.
Metabolism Diphenhydramine hydrochloride is metabolized in hepatic and renal. Guafenesin is rapidly hydrolyzed (60% within seven hours) and then excreted in the urine with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.
Elimination Urinary excretion of unchanged diphenhydramine is 1.9% and elimination half-life of Guafenesin is 1-5 hours.
Nixcof® is indicated to get relief from cough and related congestive symptoms.
12 years & above: Two 5 ml spoonful 4 times a day.
This combination shows CNS depressant effects with alcohol and other CNS depressants including barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and anti-psychotics with other drugs of similar properties such as atropine and some anti-depressants & recommended not to be taken in patients taking monoamine oxidase inhibitors (MAOIs) or within 14 of stopping treatment as there is a risk of serotonin syndrome.
Over dosage Antihistamine over dosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in children.
There is no specific data on use of this combination during pregnancy & lactation.
This combination should not combine with other medications for cough and colds. Alcohol must be avoided. This combination may impair ability to drive or operate machinery.
Store in a cool (Below 25°C temperature) and dry place protected from light.