Folic® OS: Each 5 ml of oral solution contains Folic Acid BP 2.5 mg.
Folic® OS is preparation of Folic acid which is the member of B-vitamin group.
Mode of action:
Folic Acid is biochemically inactive, so it is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase (DHFR). These Folic Acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
Folic® OS is indicated for the treatment of:
Children:Child up to 1 year: 0.5 mg/kg daily.
Over 1 year: 10 ml daily for 4 months.
Adult:Initially: 10 ml daily for 4 months.
Maintenance: 10 ml every 1-7 days depending on the underlying disease.
There are no drug drug interaction have been reported.
Over dosage:
Doses of folic acid exceeding the Recommended Dietary Allowance (RDA) should not be included in multivitamin preparations; if therapeutic amounts are necessary, folic acid should be given.
Folic acid is one of the few FDA recommended pregnancy category A drug. Safe before, during & after pregnancy & lactation as well.
It should be used with caution in patients who may have folate dependent tumours. It should never be given alone or in conjunction with inadequate amounts of vitamin B12 for the treatment of undiagnosed megaloblasticanaemia. In elderly people a cobalamin absorption test should be done before long term folate. No harmful results found from short courses of folate.
Keep out of the reach of children. Store in a dry place, below 25°C temperature and protected from light.