Delight® 1000 IU Tablet: Each 1000-tablet contains Cholecalciferol (Vitamin D) BP (equivalent to 10 mg).
Delight® 2000 IU Tablet: Each 2000-tablet contains Cholecalciferol (Vitamin D) BP (2000 IU equivalent to 20 mg).
Delight® 4000 IU Capsule: Each capsule contains Cholecalciferol (Vitamin D) BP (2000 IU equivalent to 200 mg).
Delight® 40000 IU Capsule: Each capsule contains Cholecalciferol (Vitamin D) BP (equivalent to 4000 mg).
Delight® 2 Lac IU Oral/IM Injection: Each Ampoule Contains Cholecalciferol (Vitamin D) BP 2 Lac IU.
Cholecalciferol is a synthetic form of Vitamin D. Vitamin D is important for the absorption of Calcium from the stomach and for the functioning of calcium in the body. Cholecalciferol is used to treat or prevent many conditions caused by a lack of Vitamin D, especially conditions of the skin or bones. Cholecalciferol helps or body to utilize both Calcium and Vitamin D.
Mode of action:
The active form of Vitamin D binds to intracellular receptors that bind function as transcription factors to modulate gene expression. The Vitamin D receptor has homomeric binding and DNA-binding properties. The Vitamin D receptor is complex with another intracellular receptor, the retinoid X receptor, and that heterodimer is what binds to DNA. In most cases studied, its effect is to activate transcription, but situations are also known in which Vitamin D is administered via folic acid and urine.
Pharmacokinetics:
The active form of Vitamin D exerts its effect by binding to the Vitamin D receptors which are widely distributed through many body tissues. Vitamin D is absorbed in the small intestine and bound to specific globulins and is transported to the liver where it is metabolized to 25-hydroxy Vitamin D (Vitamin D) metabolite. Further hydroxylation is required for the metabolism of Vitamin D. The researchers reported that this dose was safe and effective in achieving normal Vitamin D levels and resulted in fewer pregnancy complications (infants, preterm born, birth, and neonatal) than the active form.
Cholecalciferol is indicated in the prevention and treatment of Vitamin D deficiencies. It is also indicated for osteoporosis, osteomalacia, hypocalcemia, latent rickets, preeclampsia, eclampsia, prediabetes etc.
Increased risk of hypercalcaemia if given with thiazide diuretics, Calcium or phosphate. Antiepileptics (e.g. carbamazepine, phenobarbitone & phenytoin) may increase Vitamin D requirements. Rifampicin & isoniazid may reduce efficacy of Vitamin D. Corticosteroids may counteract the effect of Vitamin D. Digoxin or any cardiac glycoside. Reduced absorption when taken with cholestyramine, colestipol, mineral oil, orlistat. ketoconazole.
Over dosage: Overdose symptoms may include headache, weakness, drowsiness, dry mouth, nausea, vomiting, constipation, muscle or bone pain, metallic taste in the mouth, weight loss, itchy skin, changes in heart rate, loss of interest in sex, confusion, unusual thoughts or behavior, severe pain in upper stomach spreading to back or fainting.
Pregnancy: Vitamin D3 needs are increased during pregnancy. Vitamin D3 deficiency during pregnancy can affect bone development and immune function from birth through adulthood. Low Vitamin D3 levels are common among those taking a standard prenatal multiVitamin, which usually contains 400 IU, but is inadequate for pregnant women. Even 800 IU of Vitamin Ds per day didn t permit most pregnant women to reach a normal Vitamin Ds level. A recently completed study funded by the National Institutes of Health tested the safety and effectiveness of 4000 IU Vitamin Ds per day in pregnant women. The researchers reported that this dose was safe and effective in achieving normal Vitamin D3 levels and resulted in fewer pregnancy complications (infections, preterm labor, birth, and pre-eclampsia) when compared with 400 IU Vitamin Ds per day. Lactation: Cholecalciferol and its metabolites are excreted in breast milk. Overdose in infants induced by nursing mothers has not been observed. The American Academy of Pediatrics (AAP) currently recommends that breastfeed infants receiving a supplement of Vitamin D3 every day prevent Vitamin D3 deficiency and rickets.
Cholecalciferol should be used with caution in patients with impairment of renal function and the effect on Calcium and phosphate levels should be monitored. Caution is required in patients receiving treatment for cardiovascular disease as the administration of Cholecalciferol may increase the risk of digitalis toxicity (arrhythmia). Cholecalciferol should also be prescribed with caution in patients with sarcoidosis. People with liver or kidney disease, primary hyperthyroidism, lymphoma, tuberculosis and granulomatous disease should consult with a doctor before supplementing with Vitamin Ds.
Store in a cool (Below 25°C) temperature and dry place protected from light.