Azicin 250 mg Tablet: Each tablet contains Azithromycin Dihydrate USP 262.025 mg equivalent to Azithromycin 250 mg.
Azicin 500 mg Tablet: Each tablet contains Azithromycin Dihydrate USP 524.05 mg equivalent to Azithromycin 500 mg.
Azicin 250 mg Capsule: Each capsule contains Azithromycin Dihydrate USP 262.025 mg equivalent to Azithromycin 250 mg.
Azicin 20 ml Granules for Suspension: After reconstitution each 5 ml contains Azithromycin 200 mg as Azithromycin Dihydrate USP.
Azicin 35 ml Granules for Suspension: After reconstitution each 5 ml contains Azithromycin 200 mg as Azithromycin Dihydrate USP.
Azicin 50 ml Granules for Suspension: After reconstitution each 5 ml contains Azithromycin 200 mg as Azithromycin Dihydrate USP.
Azicin 1 gm Sachet: After reconstitution each 30 ml contains Azithromycin 1 gm as Azithromycin Dihydrate USP.
Azithromycin (Azicin ) is a potent member of azalides, a subclass of macrolides. Azithromycin is active against both Gram-positive and Gram-negative organisms and against mycoplasma and chlamydia.
Mode of action:
Azithromycin (Azicin ) binds to 50s ribosomal subunit of bacteria and inhibits the protein synthesis by blocking the translocation process.
Pharmacokinetics:
Azithromycin (Azicin ) is rapidly absorbed from the small intestine with peak plasma concentrations (Cmax) of 0.4 mg/L being attained 2-3 hours after a single 500 mg oral dose. Absorption is reduced by approximately 50% in the presence of food in the stomach and peak serum levels, but not the total extent of absorption are reduced by the presence of antacid containing aluminium or magnesium. The concentration of azithromycin in most tissues generally exceeds that in the serum by 10 to 100 fold. Azithromycin is widely distributed throughout the body. High concentrations are found in prostate, pulmonary tissue, tonsillar tissue, gastric mucosa, liver and gynaecological tissue, even 4-5 days after a single dose. These sustained tissue concentrations are significantly above the MIC90 values for most common pathogens. However concentrations in the brain are low, even after multiple doses. Most of the dose of azithromycin remains unmetabolized. The main route of elimination is billiary excretion. There is some metabolism in the liver, the metabolites being excreted in the bile. A small amount of the drug is excreted unchanged in the urine.
Respiratory tract infections, otitis media, skin and soft tissue infections, diarrhea, cholera, typhoid fever, uncomplicated genital chlamydial infections and non-gonococcal urethritis, gonorrhea.
Adults: For respiratory tract infections including bronchitis, pneumonia, sinusitis, pharyngitis/tonsillitis, otitis media and skin and soft tissue infections, the total dose of azithromycin is 500 mg once daily for 3 days. An alternative to this dosage schedule is that 500 mg once daily on day 1, followed by 250 mg once daily for next 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis, the dose of azithromycin is 1 gm given as a single dose. Alternatively, 500 mg once daily on.
day 1, followed by 250 mg once daily for next 2 days may also be given. For the treatment of cholera caused by Vibrio cholerae, the dose of azithromycin is 1 gm as a single dose. For the treatment of uncomplicated gonorrhea (urethritis or cervicitis) caused by Neisseria gonorrhoeae, a single 2 g dose of azithromycin may be given. Taking the dose with food may minimize adverse effects. For non-gonococcal urethritis, shigella infection, traveler s diarrhea, the usual oral is 1 gm administered as a single dose. For uncomplicated typhoid fever caused by susceptible salmonella, the dose is 1 gm once daily for 5 days. Use in the elderly: Normal adult dosage is recommended. Children: The dose of azithromycin in children over 6 months of age is 10 mg/kg body weight once daily for 3 days. For children the dose of azithromycin suspension is as follows:
Body weight (age) Dose Total volume 15-25 kg (3-7 years) 200 mg 5 ml daily for 3 days 15 ml 26-35 kg (8-11 years) 300 mg 7.5 ml daily for 3 days 22.5 ml 36-45 kg (12-14 years) 400 mg 10 ml daily for 3 days 30 ml.
As per doctors recommendation 50 ml.
& duration.
For children having body weight over 45 kg, normal adult is recommended.
Absorption of azithromycin is reduced by 50% in presence of food in stomach. It also interacts with antacid, ergot derivatives- digoxin and cyclosporine, warfarin, theophylline, carbamazepine, methylprednisolone and cimetidine.
Overdosage: There are no data available on overdosage with azithromycin. Typical symptoms of overdosage with macrolide antibiotics include hearing less, severe nausea, vomiting and diarrhoea. Gastric lavage and general supportive measures are indicated.
Pregnancy Category B: and recommended to use.
Caution should be taken in patients with renal impairment and ventricular tachycardia.
Keep out of reach of children. Store in a dry place, below 25 C temperature and protected from light.