Avemec® 3 mg Tablet: Each tablet contains Ivermectin BP 3 mg.
Avemec® 6 mg Tablet: Each tablet contains Ivermectin BP 6 mg.
Avemec® 12 mg Tablet: Each tablet contains Ivermectin BP 12 mg.
Ivermectin is a semi-synthetic, Anthelmintic agent derived from the class of Avemectins which is highly active broad spectrum anti-parasitic agent used to treat many types of parasite infestations like Scabies, River blindness (onchocerciasis), Strongyloidiasis, Trichuriasis, Ascarisiasis and Lymphatic Filariasis. Ivermectin is also being studied as a potential antiviral agent against the chikungunya and yellow fever.
Mode of action Ivermectin selectively binds and with high affinity to glutamate-gated chloride ion channels, which occur in intervertebrate nerve and muscle cells leading to an increase in the permeability of cell membranes to chloride ions with hyperpercolation of the nerve or muscle cell and ultimately ensures death of the parasite.
Parasite infestations includes Scabies, River blindness (onchocerciasis), Strongyloidiasis, Trichuriasis, Ascarisiasis and Lymphatic Filariasis etc.
Usual Adult Dose for River blindness (Onchocerciasis): 0.1 mg/kg orally once every 12 months. Patients with heavy ocular infection may require treatment every 6 months. Retreatment may be considered at intervals as short as 3 months.
Dosage guidelines based on body weight:
Weight.
Dose:
Daily.
15 to 25 kg.
3 mg.
Once.
26 to 44 kg.
6 mg.
Once.
45 to 64 kg.
9 mg.
Once.
65 to 84 kg.
12 mg.
Once.
85 kg or more.
0.15 mg/kg.
Once.
Usual Adult Dose for Strongyloidiasis: 0.2 mg/kg orally once. In immunocompromised (including HIV) patients, the treatment of strongyloidiasis may be refractory requiring repeated treatment (i.e. every 2 weeks) and suppressive therapy (i.e. once a month).
Dosage guidelines based on body weight:
Weight.
Dose:
Daily.
15 to 24 kg.
3 mg.
Once.
25 to 35 kg.
6 mg.
Once.
36 to 50 kg.
9 mg.
Once.
51 to 65 kg.
12 mg.
Once.
66 to 79 kg.
15 mg.
Once.
80 kg or more.
0.2 mg/kg.
Once.
Usual Adult Dose for Ascarisiasis: 0.2 mg/kg orally once.
Usual Adult Dose for Cutaneous Larva Migrans: 0.2 mg/kg orally once.
Usual Adult Dose for Filariasis: 0.2 mg/kg orally once.
Usual Adult Dose for Scabies: 0.2 mg/kg orally once, and repeated in 2 weeks. Ivermectin therapy may be combined with a topical scabicide.
Usual Pediatric Dose for Filariasis: Bancroftian filariasis: 5 years or older: 0.4 mg/kg orally once yearly (with a single annual dose of diethylcarbamazine 6 mg/kg), for 4 to 6 years.
Pregnancy Category C: During pregnancy, this medication should be used only when clearly needed. Ivermectin passes into breast milk. Though there have been no reports of harm to nursing infants.
If any hypersensitivity reaction to this product occurs, no further dose should be given.
Keep out of reach of children. Store in a cool (Below 30°C temperature) and dry place protected from light.