Onvicon Plus Suspension: Each 5 ml contains Sodium Alginate BP 250 mg, Sodium Bicarbonate BP 133.5 mg & Calcium Carbonate BP 80 mg.
Onvicon DX Suspension: Each 5 ml contains Sodium Alginate BP 500 mg, Sodium Bicarbonate BP 267 mg & Calcium Carbonate BP 160 mg.
The mode of action of the product is physical and does not depend on absorption into the systemic circulation. On ingestion, the product reacts rapidly with gastric acid to form a raft of Alginic acid gel having a near neutral pH and which floats on the stomach contents quickly and effectively impeding gastro-esophageal reflux, for up to 4 hours. In severe cases, the raft itself may be refluxed into the esophagus in preference to the stomach contents and exert a demulcent effect.
Gastric reflux, heartburn, flatulence associated with gastric reflux, heartburn of pregnancy, all cases of epigastric and retrosternal distress where the underlying cause is gastric reflux.
a) Route of administration: Oral.
Adult and children over 12 years: 10-20 ml after meals and at bedtime, up to four times a day.
Children 6 to 12 years: 5-10 ml after meals and at bedtime, up to four times a day.
Children under 6 years: Not recommended.
Elderly: No dosage modification is required for this age group.
a) With medicine: A time-interval of 2 hours should be considered between this drug intake and the administration of other medicinal products, especially Tetracyclines, Digoxin, Fluoroquinolone, Iron salt, Ketoconazole, Neuroleptics, Thyroid Hormones, Penicillamine, beta-blockers (Atenolol, Metoprolol, Propranolol), Glucocorticoid, Chloroquine and Bisphosphonates (diphosphonates) and Estramustine.
b) With food & other: Not applicable.
Overdose:
In the event of over dosage symptomatic treatment should be given.
Pregnancy: Clinical studies in more than 500 pregnant women as well as a large amount of data from post-marketing experience indicate no malformative nor feto/neonatal toxicity of the active ingredients. This drug can be used during pregnancy, if clinically needed.
Lactation: No effects of the active substances have been shown in breastfed newborns/infants of treated mothers. This drug can be used during breast-feeding.
Fertility: Pre-clinical investigations have revealed Alginate has no negative effect on parental or offspring fertility or reproduction. Clinical data do not suggest that this drug has an effect on human fertility.
Use in children and adolescents is given in dose and administration.
If symptoms do not improve after 7 days, the clinical situation should be reviewed.
Onvicon plus contains (6.2 mmol/10 ml) of sodium & Onvicon DX contains (5.56 mmol/10 ml) of sodium. This should be taken into account when a highly restricted salt diet is recommended. e.g., in some cases of congestive cardiac failure and renal impairment.
Onvicon plus contains (1.6 mmol/10 ml) of Calcium Carbonate & Onvicon DX contains (3.25 mmol/10 ml) of Calcium Carbonate. Care needs to be taken in treating patients with hypercalcemia, nephrocalcinosis and recurrent calcium containing renal calculi.
Store below 30°C. Protect from light. Keep all medicines out of the reach of children. Do not refrigerate or freeze.