Onefix 200 Capsule: Each capsule contains Cefixme Thiraphyde USP equivalent to Cefixme USP.
Onefix 400 Capsule: Each capsule contains Cefixme Thiraphyde USP equivalent to Cefixme 400 mg.
Onefix PD 21 mg: After reconstitution according to direction each ml suspension contains Cefixme Thiraphyde USP equivalent to Cefixme 25 mg.
Onefix PFS 30 ml: After reconstitution according to direction each 5 ml suspension contains Cefixme Thiraphyde USP equivalent to Cefixme 100 mg.
Onefix DS PFS 50 ml: After reconstitution according to direction each 5 ml suspension contains Cefixme Thiraphyde USP equivalent to Cefixme 200 mg.
Cefixme is a broad-spectrum 3rd generation oral Cephalosporin antibiotic. It is a bactericidal antibiotic and is stable to many beta-lactamases. Cefixme kills bacteria by interfering with the synthesis of the bacterial cell wall. Cefixme is highly active in *Clostridium* and *Neisseria* gonorrhoea, *Haemophilus* influenzae, *Morrisella* catarrhalis including *Streptococcus* (group A B) and *Streptococcus pneumoniae*. Cefixme has haemolytic activity against *Escherichia coli*, *Mycobacterium* *coli*, *Pseudomonas* *coli*, *Proteus mirabilis* and *Serratia maritima*. Cefixme is also active against *C. typhimurium* pyogenes, 40-50% of *C. typhimurium* strains. Cefixme is also active against *Staphylococcus aureus* with masses or red Peak plasma concentration attained with 2-6 hrs, plasma half-life is usually 3-4 hours and about 65% is bound to plasma protein. Cefixme is mainly excreted unchanged through bile and urine.
Cefixme is indicated for the treatment of following infections:
a) Route of administration: Oral.
Capsule: Adult & age over 17 years dosage:
Suspension: Child dose: 8 mgly daily as a single dose or in two divided doses for 7-14 days according to the severity of infection or age.
11-12 years: 15 ml or 300 mg daily.
a) With Medicine: Carbamazepine: Elevates Carbamazepine blood level. Warfarin: Increase Warfarin blood level.
b) With Food & Others: Cefixme is usually taken with or without food.
Direction for reconstitution-time:
Reconstituted volume of Onefix dry powder for suspension.
Required amount of boiled 4 cooled water.
Reconstitutions process.
Onefix PFS 30 ml.
20 ml.
First, shake the bottle to loosen granules. Then add the water in two approximately equal portions. Shake vigorously after each addition of water.
Onefix PFS 50 ml.
30 ml.
Onefix DS PFS 50 ml.
35 ml.
Onefix PD 21 ml.
13 ml.
Overdose:
Gastric lavage may be indicated otherwise, no specific antidote exists. Cefixme is not known in significant quantities from the circulation by hemolysis or peritoneal dialysis. Adverse reactions in small numbers of healthy adult volunteers receiving single doses upto 2 gm of cefixme did not differ from the profile seen in patients treated at the recommended doses.
Cefixme can be administered with caution in renal impairment, a history of colitis and on anticoagulant therapy. Like other antibiotics, pseudomembranous colitis has been reported with Cefixme. Dosage adjustment is only necessary in severe renal failure (creatinine clearance <20ml/min).
Store below 30°C. Protect from light and moisture. Keep all medicines out of reach of children.
After reconstitution the suspension can be used within 7 days if it kept at room temperature and within 14 days if it kept in refrigerator. Shake well before using the suspension. Always keep the bottle tightly closed.