Lizobest®: Each unit contains zbest Linezolid USP Competition Lizebest 400 Tablet: Each film coated tablet contains Linezolid USP 400 mg Lizebest 600 Tablet: Each film coated tablet contains Linezolid USP 600 mg Lizebest PFS 100 ml: After reconstitution according to direction, each 5 ml suspension contains Linezolid USP 100 mg..
Linezolid is a synthetic, antibacterial agent belonging to a new class of antibiotics, the oxazolidines, with in vitro activity against Gram positive and Gram-negative bacteria. Some Gram-negative organisms, including certain Gram-negative bacteria, is selectively inhibits bacterial protein synthesis via a mechanism of action different from that of other antibacterial agents. Linezolid binds to the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome and prevents the formation of a function 70S initiation complex which is an essential component of the bacterial translation process. The results of time-kil studies have shown, Linezolid is the bactericidal agent and staphylococci. For streptococci: Linezolid was found to be bactericidal for the majority of strains.
Linezolid is indicated for the treatment of:
a) Route of administration: Oral.
Infection.
Dosage & Route of Administration.
Adults & Adolescents (12 years and older).
Duration (days).
Nosocomial Pneumonia.
Pediatric Patients (Birth through 11 years of age).
Community-acquired pneumonia, including concurrent bacteremia.
10 mg/kg intravenous or oral every 12 hours.
600 mg intravenous or oral every 12 hours.
10 to 14 days.
Complicated oral and skin structure infections.
Vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia.
10 mg/kg intravenous or oral every 8 hours.
intravenous or oral every 12 hours.
14 to 28 days.
Uncomplicated oral and skin structure infections.
<5 days: 10 mg/kg oral every 12 hours.
5-11 years: 10 mg/kg oral every 12 hours.
Adults: 400 mg oral every 12 hours.
Adolescents: 600 mg oral every 12 hours.
10 to 14 days.
a) With Medicines: (1) Monosamine Oxidase Inhibitor: Linezolid is a reversible, nonselective inhibitor of monoamine oxidase. Therefore, linezolid is the potential for interaction with adrenergic and serotonergic agents. (2) Adrenergic Agents: Some individuals receiving linezolid may experience a reversible enhancement of the pressure response to indirect acting sympathomimetic agents, vasopressors or dopaminergic agents. Commonly used drugs such as tyramine/propylmercapturic acid and diphenhydramine have been specifically studied. Initial studies of adrenergic agents, such as dopamine or epinephrine, should be reduced and titrated to achieve the desired response. (3) Serotonergic Agents: Physicians should be alert to the possible signs and symptoms of serotonergic syndrome in patients receiving concomitant linezolid and serotonergic.
b) With Medicines: There are no specific foods that must be excluded from diet when consuming this medication.
Direction for reconstitution of suspension:
First, shake the bottle to loosen powder. Then add 45 ml (with the help of given measuring cup) of boiled and cooled water. For the ease of preparation, add water in two portions. Shake well after each addition until all the powder is in suspension.
Overdose:
No case of overdose has been reported. Symptomatic and supportive care is advised together with maintenance of glomerular filtration. Approximately 30% of a linezolid dose is removed during 3 hours of hemodialysis. No data are available or hemopterom.
Patients who develop acute nausea or vomiting, unexplained acidosis, or low bicarbonate level while receiving linezolid should receive immediate medical evaluation. When administered by linezolid and concomitant serotonergic agents is clinically appropriate, patients should be closely observed for signs and symptoms of serotonin syndrome such as cognitive dysfunction, hyperpyrexia, hyper reflexia and incoordination. If signs or symptoms of serotonin syndrome should consider discontinuation of linezolid or both agents. If the concomitant serotonergic agent is withdrawn, discontinuation symptoms can be observed. If patients experience symptoms of serotonin syndrome, such as changes in visual acuity, changes in color vision, blurred vision, or visual field defect, prompt psychopharmacological evaluation is recommended. Conclusions have been reported in patients when treated with linezolid. In some of these cases, a history of seizures or risk factors for seizures was reported.
Store below 30°C. Protect from light and moisture. Keep all medicines out of reach of children. The reconstituted suspension should be stored in a cool and dry place. Use within 21 days after reconstitution.