Folidid 5 Tablet: Each tablet contains Calcium Folate Hydrate BP equivalent to Folinic Acid 5 mg.
Calcium Folate is a Calcium salt (Leucovorin Calcium) of Folinic acid, is a mixture of the diastereoisomers of the 5-formyl derivative of Tetrahydrofolic Acid. It is a metabolite of Folic Acid and able to bypass DHFR reduction, which acts as a cellular substitute for the co-factor THF, thereby used in cytotoxic therapy. Folic Acid is an essential B vitamin required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. However, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the co-factors dihydrofolate (DHF) and tetrahydrofolate (THF).
It is indicated for:
a) Route of administration: Oral.
a) With Medicine: Many cytotoxic medicinal products - direct or indirect DNA synthesis Inhibitors (hydroxycarbamide, cytarabine, mercaptopurine, thioguanine) lead to macrocytosis, such macrocytosis should not be treated with Folinic acid. In epileptic patients treated with Phenobarbital, Phenytoin, Primidone, and Succinimides, there is a risk to increase the frequency of seizures due to a decrease of plasma concentrations of anti-epileptic drug.
b) With food & others: No adequate data are available.
Overdose:
There have been no reported sequelae in patients who have received significantly more Calcium Folate than the recommended dosage. However, excessive amounts of Calcium Folate may nullify the chemotherapeutic effect of folic acid antagonists.
Not known to be harmful for pregnant women. It may be given if benefit outweighs risk during pregnancy. Presence in milk is unknown in lactation.
Store below 30°C. Protect from light and moisture. Keep all medicines out of reach of children.