Bilbest 20 mg Tablet: Each film coated tablet contains Bilastine INN 20 mg.
Bilbest 60 ml Syrup: Each 5 ml syrup contains Bilastine INN 12.5 mg.
It is a non-sedating, long-acting H1 receptor selective antagonist. Its effects are mediated via selective inhibition of peripheral H1-receptors. It shows moderate to high affinity for histamine H1-receptors and no affinity for muscarinic, serotonergic, dopaminergic and noradrenergic receptors. It inhibits histamine induced flare skin reactions for 24 hours following single doses.
For the symptomatic relief of symptoms of allergic rhinitis, rhino conjunctivitis and urticaria (pruritus and hives).
a) Route of administration: Oral.
Children between 2 to 11 years: Bilbest Syrup: 4 ml once daily.
Bilbest 20 Tablet: 20 mg Tablet once daily. To achieve optimal exposure to Bilastine, once daily dose should be taken with water on an empty stomach.
a) With medicine: Concomitant intake of Ketoconazole, Erythromycin or Diltiazem increases the concentration of this drug. The psychomotor performance after concomitant intake of alcohol and this drug was similar to that observed after the intake of alcohol and placebo. Concomitant intake of this drug and Lorazepam 3 mg for 8 days did not potentiate the depressant CNS effects of Lorazepam.
b) With food and others: Food significantly reduces the oral bioavailability of this drug by 30%. Interaction with grapefruit juice: concomitant intake of this drug and grapefruit juice decreased bioavailability by 30%. This effect may also apply to other fruit juices.
Overdose:
No serious adverse events have been reported in case of over dosage. However, in the event of overdosage, symptomatic and supportive treatment have been reported.
There are no adequate and well-controlled studies in pregnant women. Until such data becomes available, this drug should be avoided during pregnancy, unless advised otherwise by a physician.
Store below 30°C. Protect from light and moisture. Keep all medicines out of reach of children.