Azikil 500 Tablet: Each film coated tablet contains Azithromycin Dihydrate USP equivalent to Azithromycin 500 mg.
Azikil 20 ml Powder for Suspension: After reconstitution, each 5 ml suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.
Azikil 35 ml Powder for Suspension: After reconstitution, each 5 ml suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.
Azikil 50 ml Powder for Suspension: After reconstitution, each 5 ml suspension contains Azithromycin Dihydrate USP equivalent to Azithromycin 200 mg.
Azithromycin is an azide antibiotic, a subclass of macrolide antibiotic. It acts by binding to the 50s ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis. Azithromycin has been shown to be active against most strains in the following microorganisms, both in vitro and in clinical infections:
Azithromycin is indicated for infections caused by susceptible organisms in:
a) Route of administration: Oral.
Azithromycin Tablet & Powder for Suspension can be taken with or without food.
Azikil: For respiratory tract infections, otitis media and skin & soft tissue infections: 500 mg once daily for 3 days or an alternative to this as 500 mg once on day 1, followed by 250 mg once daily for next 4 days.
b) For sexually transmitted diseases, like genital ulcer: non-gonococcal urethritis and cervicitis due to *Chlamydia trachomatis*: a single 1 gm (1000 mg) dose.
c) For the treatment of urethritis and cervicitis due to *Neisseria gonorrhoeae*: a single 2 gm (2000 mg) dose. In typhoid, 500 mg once daily for 7 days.
d) In Children, a single 1 gm (1000 mg) dose.
e) In Shigellosis, 500 mg once on day 1, followed by 250 mg once daily for next 4 days.
Children:
Age/body weight.
Daily dose.
Measuring cup/poon.
Duration.
From 1 month.
10 mg/kg.
According to Physician’s recommendation.
3 days.
15-25 kg.
200 mg.
5 ml (1 tea spoonful).
3 days.
26-35 kg.
300 mg.
7.5 ml (1/2 tea spoonful).
3 days.
36-45 kg.
400 mg.
10 ml (2 tea spoonful).
3 days.
a) With medicine: Peak serum levels but not the total extent of absorption were reduced by the presence of magnesium and aluminum-containing antacids. Azithromycin should be taken at least 1 hr before or 2 hr after these antacids. In patients receiving ergot alkaloids, Azithromycin should be avoided concurrently because of the possibility of ergotism result in from interaction of Azithromycin with the cyclosporine P-450 system. However, no cases of such interaction have been reported. Macrolides have been known to increase the plasma concentration of dipom and cyclosporine. Therefore, if co-administration is necessary caution should be exercised and serum levels of dipom and cyclosporine should be checked.
b) With four 6 others: No adequate data are available.
Direction for reconstitution of suspension:
Shake the bottle to loosen powder.
For ease of preparation, add boiled and cooled water in two proportions. Shake well after each addition until all the powder is in suspension.
Overdose:
There are no data available on overdose with Azithromycin. Typical symptoms of overdose with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhea. Gastric lavage and general supportive measures are indicated.
Pregnancy: U.S. FDA, pregnancy category B. In the animal studies, no evidence of harm to the fetus due to Azithromycin was found.
Lactation: It is not known whether Azithromycin is excreted in human milk. Caution should be exercised when administered to nursing mother.
Should be used as per direction of physician.
As with any antibiotic, observation for signs of super infection with non-susceptible organisms, including fungi, is recommended. Precaution should be taken in patients with more severe renal impairment.
Store below 30°C. Protected from light. Keep all medicines out of reach of children.