Nervalin® CR 82.5 Tablet: Each extended release tablet contains Pregabalin EP 330 mg.
Nervalin® CR 165 Tablet: Each extended release tablet contains Pregabalin EP 165 mg.
Nervalin® CR 82.5 Tablet: Each extended release tablet contains Pregabalin EP 82.5 mg.
Nervalin® Oral Solution: Each 5 ml contains Pregabalin EP 100 mg.
Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body.
Recommended Dosage Nervalin® CR Tablet:
Indication
Dosing Regimen.
Initial Dose.
Maximum Dose.
DPN Pain.
Single dose per day.
165 mg/day.
300 mg/day within 1 week.
Postherpetic neuralgia.
Single dose per day.
165 mg/day.
300 mg/day within 1 week. Maximum dose of 660 mg/day.
Conversion from Pregabalin Capsule to Nervalin® CR Tablet:
Pregabalin Total Daily Dose (dosed 2 or 3 times daily).
Pregabalin CR Dose (dosed once a day).
75 mg/day.
82.5 mg/day.
300 mg/day.
165 mg/day.
300 mg/day.
300 mg/day.
Recommended Dosage for Nervalin® Oral Solution:
Dosing recommendations:
Indication
Dosing Regimen.
Maximum Dose.
DPN Pain.
3 divided doses per day.
300 mg/day within 1 week.
Postherpetic neuralgia.
2 or 3 divided doses per day.
300 mg/day within 1 week. Maximum dose of 600 mg/day.
Adjunctive Therapy for Adult Patients with Partial Onset Seizures.
2 or 3 divided doses per day.
Maximum dose of 600 mg/day.
Fibromyalgia.
2 divided doses per day.
300 mg/day within 1 week. Maximum dose of 450 mg/day.
Neuropathic Pain Associated with Spinal Cord Injury.
2 divided doses per day.
300 mg/day within 1 week. Maximum dose of 600 mg/day.
No pharmacokinetic interactions were observed between Pregabalin and erythromycin, carbamazepine, gabapentin, lamotrigine, oral contraceptive, phenobarbital, phenytoin, topiramate, and valproic acid.
Overdosage
The highest reported accidental overdose of Pregabalin during the clinical development program was 8000 mg, and there were no notable clinical consequences.
Pregnancy Category C.
Lactation: Small amount of Pregabalin excreted in human milk; however, the effects on breastfed infant is not known. Decide to discontinue nursing or drug according to the importance of the drug.
Pediatric Use: The safety and efficacy of Pregabalin in pediatric patients have not been established.
Geriatric Use: In controlled clinical studies no overall differences in safety and efficacy were observed between geriatric patients and younger patients.
Renal Impairment: Pregabalin is known to be excreted by the kidney, and the risk of toxic reactions to Pregabalin may be greater in patients with impaired renal function. Adjust the dose for elderly patients with renal impairment.
Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.