ICOL Eye & Ear Drops: Each ml contains Chloramphenicol BP 5 mg.
Chloramphenicol is a potent,broad spectrum antibiotic which is-effective against a wide range of gram-positive and gram-negative bacteria and also effective against Spirochaete,Salmonella,Rickettsiae and Chlamydiae (trachoma) . Chloramphenicol is primarily a bacteriostatic,readily penetrates into bacterial cells and acts by inhibition on proiein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes. It has been noted that Chloramphenicol is found in practical measurable amounts in the aqueous humor following local application to the eye.
Uses As a broad spectrum antibiotic ICOL ® can be used in a variety of infections caused by susceptible organisms, such as conjunctivitis, blepharitis, corneal ulcer, dacryocystitis etc. ICOL ® is active against the common bacterial eye pathogens listed below: Staphylococcus aureus, Streptococci including Streptococcus pneumoniae, E.coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, Moraxella lacunata. Chloramphenicol can destroy or inhibit the susceptible organisms present in the ear canal. Directions for Use The following steps should be considered to ensure the right use of ICOL ® a. Proper administration technique for applying the solution to the eye and ear. b. Compliance with full course of therapy. c. Missed dose: Applying as soon as possible; not applying if almost time for the next dose. d. Close bottle immediately after use. e. Proper storage of the medicament. Do not use longer than one month after opening. It is advisable to destroy any remaining medicament after completing treatment.
No Data
Eye Two drops applied to the affected eye every three hours, or more frequently if deemed advisable by the prescribing physician. Administration should be continued day and night for the first48 hours, after which the interval between applications may be increased. Treatment should be continued for at least 48 hours after the eye appears normal. Ear 2-3 drops into the ear canal twice or thrice daily. Paediatric Use No specific data are available and thus no specific dosage recommendation can be given.
Inhibits CYP2C9 and CYP3A4: increases plasma levels of phenytoin, tolbutamide, and chlorpropamide; penicillins and cephalosporins have bactericidal action antagonized.
Hypersensitivity to the ingredients, acute intermittent porphyria, severe blood disorders and hepatic disfunctions due to the bone marrow depression, new-born, family history of bone marrow dep ession.
Common: Slight ocular burning sensation, bitter taste. Rare: Palpebral eczema, aplastic anemia, pancytopenia, leukopenia, thrombocytopenia, agranulocytosis.
Overdose
No Data
Category C (Contraindicated at term / labor). Crosses placenta; risk of neonatal toxicity and 'gray baby syndrome'; contraindicated near term. Lactation: Excreted in breast milk; contraindicated in nursing mothers.
Store below 25°C in a tight, light-resistant container. Protect from light and moisture.