Each ml contains:
Active Substance: Fluorometholone USP 1 mg.
Preservative: Benzalkonium Chloride 0.1 mg.
Fluromet is a sterile ophthalmic suspension containing Fluorometholone - a corticosteroid for topical administration to the eyes.
Clinical Pharmacology:
Fluorometholone is a corticosteroid with an excellent anti-inflammatory action with no significant influence on the intraocular pressure. The anti-inflammatory activity of Fluorometholone is at least 40 times stronger than that of Hydrocortisone.
Corticosteroids are thought to act by the introduction of phospholipase A₂ inhibitory proteins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandin and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A₂. In comparison with other corticosteroids Fluorometholone is more rapidly degraded in tissue and therefore has less effect on the intraocular pressure. The immunosuppressive action of Fluorometholone is less pronounced than that of Dexamethasone.
Fluromet ophthalmic suspension is indicated for the treatment of.
1 drop 2-4 times daily in the conjunctival sac(s).
During the first 24-48 hours the dosage can be increased to 1 drop hourly.
*Prescription only*
Specific drug interaction studies have not been conducted with Fluorometholone ophthalmic suspension.
Overdose:
Overdose through local administration is not known and not likely.
Animal experiments with Fluorometholone have shown adverse effect on the fetus. However, Fluorometholone ophthalmic suspension should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Corticosteroids may mask, activate or aggravate an infection of the eye. If no improvement is seen after a few days of application, other form of treatment should be used. Do not touch dropper tip to any surface as this may contaminate this preparation.
Store at below 30°C in a dry place protected from light and freezing. It is desirable that the contents should not be used more than one month after first opening of the bottle.