Fluclox 250mg Capsule: Each capsule contains Flucloxacillin 250mg as Sodium BP.
Fluclox 500mg Capsule: Each capsule contains Flucloxacillin 500mg as Sodium BP.
Fluclox Powder for Suspension (125mg/5ml): When reconstituted each 5ml contains Flucloxacillin 125mg as Sodium BP.
Fluclox DS Powder for Suspension (250mg/5ml): When reconstituted each 5ml contains Flucloxacillin 250mg as Sodium BP.
Fluclox 250mg injection: Each vial contains Flucloxacillin 250mg as Sodium BP.
Fluclox 500 mg injection: Each vial contains Flucloxacillin 500 mg as Sodium BP.
Fluclox ® is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by beta-lactamase-producing Staphylococci. Typical indications include: Skin and soft tissue infections: Boils, abscesses, carbuncles, infected skin conditions, for example, ulcers, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns, protection for skin grafts, otitis media, and external impetigo. Respiratory tract infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy. Other infections caused by Fluclox ® -sensitive organisms: Osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, septicaemia. Fluclox ® is also indicated for use as a prophylactic agent during major surgical procedures, where appropriate; for example, cardiothoracic and orthopaedic surgery.
No Data
Adults (including elderly patients):
Oral : 250-500mg four times daily, administered ½ to 1 hour before meals.
Intramuscular : 250mg four times daily.
Intravenous : 250-500mg four times daily. (Doses may be doubled where necessary).
Osteomyelitis, endocarditis : Up to 8g daily, in divided dosages 6 to 8 hourly.
Surgical prophylaxis : 1 to 2g IV at induction of anaesthesia followed by 500mg six hourly, IV, IM or orally for up to 72 hours.
Other routes: Intrapleural: 250mg once daily; Intra-articular: 250-500mg once daily; Nebuliser: 125-250mg four times daily.
Children: 2-10 years: ½ of adult dose; Under 2 years: ¼ of adult dose. (Or 12.5 to 25 mg/kg four times daily).
Renal impairment: In severe renal failure (CrCl <10ml/min) reduce dose or extend interval.
Administration: IM: Reconstitute 250mg in 1.5ml WFI, 500mg in 2ml WFI. IV: Dissolve 250-500mg in 5-10ml WFI, slow IV (3-4 min).
Probenecid reduces renal tubular clearance of flucloxacillin; methotrexate clearance is decreased increasing toxicity; may reduce efficacy of oral contraceptives.
Penicillin hypersensitivity; ocular administration.
Less Common: Nausea, diarrhea, skin rashes. Rare: Hepatitis, cholestatic jaundice, pseudomembranous colitis.
Overdose
Problems of over dosage with Flucloxacillin are unlikely to occur; if encountered they may be treated symptomatically.
Category B. Animal studies show no teratogenic effect; use in pregnancy only when considered essential by clinician. Lactation: Trace quantities detected in breast milk; caution advised.
No Data
Store below 25°C in a cool, dry place. Protect from light. Reconstituted suspension is stable for 7 days at room temp or 14 days refrigerated.