Prescription Required: Registered Medical Practitioner's prescription is required to purchase this product.

Human

Flubac

Capsule

250 mg

GENERIC NAMEFlucloxacillin

MANUFACTURED BYPopular Pharmaceuticals PLC

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Available Pack Sizes:4 Sizes

Purchase Option:Full Pack

Maximum Retail Price (MRP):

Quantity

৳ 28.80/ 4 x 13

(Unit: ৳ 8.00 / 1 Capsule)

16263

Composition

Flubac 250 capsule: Each capsule contains Flucloxacillin Sodium BP equivalent to 250 mg Flucloxacillin.

Flubac 500 capsule: Each capsule contains Flucloxacillin Sodium BP equivalent to 500 mg Flucloxacillin.

Flubac powder for syrup: After reconstitution each 5 ml syrup contains Flucloxacillin Sodium BP equivalent to 125 mg Flucloxacillin.

Flubac DS powder for syrup: After reconstitution each 5 ml syrup contains Flucloxacillin Sodium BP equivalent to 250 mg Flucloxacillin.

Description

Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric acid stability and activity against gram-positive bacteria. Flucloxacillin is a bactericidal antibiotic that is particularly useful against penicillinase-producing staphylococci. Flucloxacillin kills bacterial cellwall, thus interfering with peptidoglycan synthesis. Peptidoglycan is a heteropolymeric structure that provides the cell wall with its mechanical stability. The final stage of peptidoglycan synthesis involves the completion of the cross-linking with the terminal glycine residue of the pentaglycin bridge linking to the fourth residue of the pentapeptide (D-alanine). The transpeptidase enzyme that performs this step is inhibited by Flucloxacillin. As a result the bacterial cellwall is weakened, the cell swells and then ruptures. Flucloxacillin resists the action of bacterial penicillinase probably because of the steric hindrance induced by the acyl side chain which prevents the opening of the β-lactam ring.

Indications

Flucloxacillin is indicated for the treatment of infections due to Gram positive organisms, including infections caused by β-lactamase producing staphylococci.

Skin and soft tissue infections: Boils, abscesses, carbuncles, furunculosis, cellulitis, infected skin conditions, e.g. ulcer, eczema and acne, infected wounds, infected burns, protection for skin grafts, otitis media and externa, impetigo.

Respiratory tract infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy.

Other infections caused by Flucloxacillin-sensitive organisms:** Osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, septicaemia Flucloxacillin is also indicated for use as a prophylactic agent during major surgical procedures where appropriate; for example, cardiothoracic and orthopaedic surgery.

Dosage & Administration

Oral administration: Oral doses should be administered half to one hour before meals. Usual adult dosage (including elderly patients): 250 mg four times daily. In severe infections, dosage should be doubled.

In osteomyelitis and endocarditis: Up to 8 gm daily, in divided doses 6 to 8 hourly. In case of secondary bacterial infection in chicken pox: Flucloxacillin 500 mg six hourly should be prescribed.

Usual children dosage: 2-10 years: Half of the adult dose. Under 2 years: Quarter of the adult dose.

Dose adjustment in renal impairment: As common with other penicillins, Flucloxacillin usage in patients with renal impairment does not usually require dosage reduction. However, in the presence of severe renal failure (creatinine clearance < 10 ml/min) a reduction in dose or an extension of dose interval should be considered. Flucloxacillin is not significantly removed by dialysis and hence no supplementary dosages need to be administered either during or at the end of the dialysis period.

Direction of Reconstitution:

Flubac powder for syrup / Flubac DS powder for syrup: Shake the bottle well before adding water. Then add 60 ml of boiled and cool water to the bottle. For ease of preparation, add the water in two portions. Shake the bottle gently until the powder is dissolved properly. Shake the bottle before each use.

*Prescription only*

Interaction

The administration of probenecid with Flucloxacillin results in higher serum peak concentrations and prolongs the time that therapeutic concentrations of Flucloxacillin are achieved in serum. Physical incompatibility and/or loss of activity of Flucloxacillin in solution has been reported when given with gentamycin sulphate, streptomycin sulphate, vitamin mixtures. Flucloxacillin should not be added to intravenous lipids, blood products and protein hydrolysates or other proteinaceous fluids.

Overdosage:

Gastrointestinal effects such as nausea, vomiting and diarrhoea may be evident and should be treated symptomatically. Flucloxacillin is not removed from the circulation by haemodialysis.

Contraindications

Flucloxacillin should not be given to patients with a history of hypersensitivity to β-lactam antibiotics (e.g. penicillins, cephalosporins) or excipients. Flucloxacillin is contra-indicated in patients with a previous history of Flucloxacillin-associated jaundice/hepatic dysfunction. Ocular administration.

Side Effects

Side effects as with other penicillin, are uncommon and mainly of a mild and transitory nature.

Gastro-intestinal upsets (e.g. nausea, diarrhoea) and skin rashes have been reported.

If skin rash occurs, treatment should be discontinued.

Precautions & Warnings

Use in pregnancy and lactation: The use of Flucloxacillin in pregnancy should be reserved for cases considered essential by the clinician. Use of the drug in the second and third trimesters may result in the sensitisation of the fetus. During lactation, trace quantities of penicillins can be detected in breast milk.

Storage Conditions

Store at below 30°C in a dry place protected from light. Keep out of reach of children.

Flubac • 4 x 13

৳ 28.80