Flamex 200 Tablet: Each coated tablet contains Ibuprofen BP 200 mg.
Flamex 400 Tablet: Each coated tablet contains Ibuprofen BP 400 mg.
Flamex Suspension: Each 5 ml contains Ibuprofen BP 100 mg.
Flamex SR Capsule: Each sustained release capsule contains Ibuprofen BP 300 mg.
Flamex is the preparation of Ibuprofen which is an NSAID, works by blocking the synthesis of prostaglandins and therefore reduces pain and inflammation. Flamex tablet is the immediate release formulation of Ibuprofen and Flamex SR capsule is a sustained release formulation of Ibuprofen. Flamex SR capsule provides more prolonged analgesic & anti-inflammatory effect than immediate release Ibuprofen.
Route of administration: Flamex can be taken orally.
Adults and children over 12 years:
Flamex:
Flamex SR:
Initially one (300 mg) or two (600 mg) capsules should be taken twice daily. Not more than 4 capsules are to be taken in 24 hours.
In children: Flamex
Mild to moderate pain, pain and inflammation of soft tissue injuries, pyrexia with discomfort:
Child 1-3 months: 5 mg/kg 3-4 times daily
Child 3-6 months: 50 mg 3 times daily (maximum 30 mg/kg daily in 3-4 divided doses)
Child 6 months-1 year: 50 mg 3-4 times daily (maximum 30 mg/kg daily in 3-4 divided doses)
Child 1-4 years: 100 mg 3 times daily (maximum 30 mg/kg daily in 3-4 divided doses)
Child 4-7 years: 150 mg 3 times daily (maximum 30 mg/kg daily in 3-4 divided doses)
Child 7-10 years: 200 mg 3 times daily (up to 30 mg/kg daily (maximum 2.4 g) in 3-4 divided doses)
Child 10-12 years: 300 mg 3 times daily (up to 30 mg/kg daily (maximum 2.4 g) in 3-4 divided doses)
Rheumatic disease in children: Child 3 months-18 years: 30-40 mg/kg (maximum 2.4 g) daily in 3-4 divided doses.
Post immunization pyrexia in infants: Child 2-3 months: 50 mg as a single dose repeated once after 6 hours if necessary.
Flamex SR is not recommended for children under 12 years of age.
Elderly: No special dosage modifications required unless renal or hepatic impairment exists.
Warfarin and antiplatelets increase gastrointestinal bleeding risk; reduces renal clearance of lithium and methotrexate; attenuates efficacy of ACE inhibitors and diuretics.
Ibuprofen is contraindicated to the patients with known hypersensitivity to this drug. It is also contraindicated in patients with a history of peptic ulceration. Bronchospasm may be precipitated in patients suffering from, or with a previous history of bronchial asthma or allergic disease. Ibuprofen should not be given to patients in whom aspirin or other NSAIDs induce the symptoms of asthma, rhinitis or urticaria.
Common: Dyspepsia, gastrointestinal intolerance, GI bleeding, skin rashes. Less Common: Thrombocytopenia.
Overdose
In case of overdose, gastric lavage and if necessary, correction of serum electrolytes have been recommended. There is no specific antidote for ibuprofen.
Category C (1st/2nd trimesters), Category D (3rd trimester). Avoid during pregnancy, contraindicated from 30 weeks gestation due to premature closure of ductus arteriosus. Lactation: Excreted in very low concentrations; compatible with breastfeeding.
Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.