Don-A® Tablet: Each film coated tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg.
Don-A® Suspension: Each 5 ml suspension contains Domperidone BP 5 mg.
Don-A® Paediatric Drops: Each ml contains Domperidone BP 5 mg.
Don-A® (Domperidone) is a dopamine receptor ($D_2$) antagonist. Don-A® (Domperidone) is a selective peripheral dopamine antagonist at the $D_2$ Dopamine receptor in the Chemo-receptor Trigger Zone (CTZ) and stomach. Don-A® (Domperidone) does not readily enter the central nervous system (the chemoreceptor trigger zone is considered to lie outside the blood brain barrier). Don-A® (Domperidone) increases spontaneous gastric activity and antagonizes dopamine inhibition of gastric emptying. Don-A® (Domperidone) has been shown to increase lower esophageal sphincter pressure and promotes esophageal and antral peristalsis and also increases pyloric dilatation. Don-A® (Domperidone) increases the frequency, amplitude, duration of duodenal contraction and reduces the small bowel transit time. Don-A® (Domperidone) has no acetylcholine like effect.
Route of administration:
Don-A® (Domperidone) should be taken 15-30 minutes before a meal. The usual recommended oral dose is as follow:
Tablet/ Suspension/ Paediatric Drops:
Or as Directed by the Physician.:
Domperidone may reduce the risk of hypoprolactinemic effect of bromocriptine. The action of Domperidone on GI function may be antagonized by antimuscarinics and opioid analgesics.
Over dosage:
There are no reported cases of over dosage.
Domperidone should be used with absolute caution in case of children because there may be an increased risk of extrapyramidal reactions in young children because of an incompletely developed blood brain barrier.
The safety of Domperidone has not been proven and it is, therefore, not recommended during pregnancy. Animal studies have not demonstrated teratogenic effect on the fetus. Domperidone may precipitate galactorrhea and improve postnatal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Store below 30°C temperature & dry place, protected from light. Keep all medicines out of reach of children.