Prescription Required: Registered Medical Practitioner's prescription is required to purchase this product.

Human

Domilux

ER Tablet

10 mg

GENERIC NAMEDomperidone

MANUFACTURED BYPopular Pharmaceuticals PLC

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Available Pack Sizes:3 Sizes

Purchase Option:Full Pack

Maximum Retail Price (MRP):

Quantity

৳ 72.00/ 20 x 7

(Unit: ৳ 4.00 / 1 Tablet)

16263

Composition

Domilux Tablet: Each film coated tablet contains Domperidone Maleate BP equivalent to 10 mg Domperidone.

Domilux Suspension: Each 5 ml suspension contains 5 mg Domperidone BP.

Domilux Pediatric Drops: Each ml pediatric drops contains 5 mg Domperidone BP.

Description

Domperidone is a dopamine antagonist that principally blocks the dopamine receptors located in the chemoreceptor trigger zone (CTZ) and stomach. Due to its weak penetration across the blood-brain barrier, Domperidone has almost no effect on the dopaminergic receptors in the brain, therefore, excluding psychotropic and neurologic side effects. Domperidone restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis and regulates contraction of the pylorus. Domperidone also increases esophageal peristalsis and lower esophageal sphincter pressure, and thus prevents regurgitation of gastric content.

Indications

Dyspeptic symptom complex, often associated with delayed gastric emptying, gastroesophageal reflux and esophagitis:

Epigastric sense of fullness, feeling of abdominal distension, upper abdominal pain.

Eructation, flatulence, early satiety.

Nausea and vomiting.

Heartburn with or without regurgitations of gastric contents in the mouth.

Diabetic gastroparesis.

Non-ulcer dyspepsia.

Acute nausea and vomiting of the functional, organic, infectious, dietetic origin or induced by radiotherapy or drug therapy or induced in migraine.

Parkinson’s disease: In dopamine-agonist induced nausea and vomiting.

Radiological studies: Speeding barium transit in follow-through radiological studies.

Dosage & Administration

Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.

Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptom:

Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.

Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily.

Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

*Prescription only*

Interaction

a) With medicine: Domperidone may reduce the risk of hypoprolactemic effect of Bromocriptine. The action of Domperidone on GI function may be antagonized by anti-muscarinics and opioid analgesics. Care should be exercised when Domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.

b) With food and others: It is recommended to take oral Domperidone tablets before meals. If taken after meals, absorption of the drug is somewhat delayed.

Contraindications

Domperidone is contraindicated to patients having known hypersensitivity to this drug and in the case of neonates. Domperidone should not be used whenever gastrointestinal stimulation might be dangerous i.e., gastrointestinal hemorrhage, mechanical obstruction or perforation. Also contraindicated in patients with prolactin releasing pituitary tumor (prolactinoma).

Side Effects

Domperidone may produce hyperprolactinemia (1.3%).

This may result in galactorrhea, breast enlargement, and soreness and reduced libido.

Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with Domperidone.

Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.

Pregnancy & Lactation

The safety of Domperidone has not been proven and it is therefore not recommended during pregnancy. Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Overdosage** There are no reported cases of overdose.

Precautions & Warnings

Domperidone should be used with absolute caution in case of children because there may be increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since Domperidone is highly metabolized in liver, it should be used with caution in patient with hepatic impairment.

Storage Conditions

Store at below 30°C in a dry place protected from light. Keep out of reach of children.

Domilux • 20 x 7

৳ 72.00