Buflex 500 Tablet: Each film coated tablet contains Nabumetone USP 500 mg.
Buflex 750 Tablet: Each film coated tablet contains Nabumetone USP 750 mg.
Buflex is a preparation of Nabumetone, a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic properties.
Nabumetone is indicated for acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
The recommended starting dose is 1,000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1,500 mg to 2,000 mg per day given as a single or twice-daily dose. In renal insufficiency (CrCl 30-49 ml/min), starting dose should not exceed 750 mg daily.
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Concomitant use with anticoagulants, aspirin, lithium, or methotrexate may increase toxicity.
Known hypersensitivity to Nabumetone; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, dizziness, headache, pruritus, and rash.
Category C (Category D in third trimester). Avoid use in late pregnancy due to risk of premature closure of ductus arteriosus.
Risk of serious cardiovascular thrombotic events, myocardial infarction, stroke; serious gastrointestinal adverse events including bleeding, ulceration, and perforation; renal papillary necrosis and other renal injury.
Do not store above 30°C. Keep in a dry place. Protect from light and keep out of reach of children.