Atofix™ 0.3% Ointment: Each box contains a tube of 10g Ointment. Each gram ointment contains Difamilast INN 3 mg.
Atofix™ 1% Ointment: Each box contains a tube of 10g Ointment. Each gram ointment contains Difamilast INN 10 mg.
Atofix™ is a preparation of Difamilast, which is a phosphodiesterase (PDE4)inhibitor. It increases cyclic adenosine 3',5'-monophosphate (cAMP) concentration and consequently suppresses the production of inflammatory cytokines, exerting effects in treatment of atopic dermatitis.
The usual adult dosage is an appropriate amount of the Difamilast 1% ointment applied to the affected area twice daily. The usual pediatric dosage is an appropriate amount of the Difamilast 0.3% ointment applied to the affected area twice daily.
Difamilast is not recommended for pregnant women or women who may possibly be pregnant. For breastfeeding, safety profile has not been fully established.
Use in Specific Population:
Do not store above 30°C temperature. Keep away from light and wet place. Keep out of reach of children.