Atasin EZ 10/10 tablet: Each coated tablet contains Atorvastatin 10 mg as Atorvastatin Calcium Trihydrate USP and Ezetimibe USP 10 mg.
Atasin EZ 20/10 tablet: Each coated tablet contains Atorvastatin 20 mg as Atorvastatin Calcium Trihydrate USP and Ezetimibe USP 10 mg.
Atasin EZ is a combination of Atorvastatin and Ezetimibe. Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Atorvastatin reduces LDL production and the number of LDL particles. Ezetimibe reduces blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. The molecular target of Ezetimibe has been shown to be the sterol transporter, which is involved in the intestinal uptake of cholesterol and phytosterols.
For adults and children Therapy of dry eye syndrome requires an individual dosage regimen. The usual dose for Alier® is 1 drop into the conjunctival sac 3 to 5 times per day or as directed by the physician.
Cyclosporine increases concentrations of both atorvastatin and ezetimibe (monitor closely); fibrates (gemfibrozil, fenofibrate) increase risk of cholelithiasis and severe myopathy; bile acid sequestrants (cholestyramine) decrease ezetimibe bioavailability (administer 2-4 hours apart); strong CYP3A4 inhibitors increase myopathy risk.
It is contraindicated in patients with history of known hypersensitivity to atorvastatin or ezetimibe or any other components of this product. It is also contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levels.
Common: Elevated ALT, elevated AST, musculoskeletal pain.
Overdose
In case of overdose, treatment should be symptomatic and supportive measures instituted as required.
Category X (Contraindicated). Fetal harm may occur; strictly contraindicated during pregnancy. Lactation: Potential for serious adverse reactions in infants; advise women not to breastfeed.
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.