Apuldon Tablet: Each film-coated tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg.
Apuldon Suspension: Each 5 ml contains Domperidone BP 5 mg.
Apuldon Paediatric Drops: Each ml contains Domperidone BP 5 mg.
Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
Recommended oral dose:
Apuldon may reduce the hypoprolactinemic effect of bromocriptine. The effect of antimuscarinics & opioid analgesics may antagonize Apuldon on GI function.
Patients with a known allergy to Domperidone or Domperidone Maleate or any inactive ingredient of the product.
Apuldon may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness & reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash & itching.
Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Apuldon may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
In case of children, treatment with Apuldon should be continued with caution because there may be increased risk of extra-pyramidal reactions in young children.
Store below 30 C, keep in dry place & protect from light. Keep out of the reach of children.