Aprocin®-500 Tablet: Each film-coated tablet contains Ciprofloxacin Hydrochloride USP equivalent to Ciprofloxacin 500 mg.
Aprocin® Taste Masked Pellets for Suspension: After reconstitution, each 5 ml suspension contains Ciprofloxacin Hydrochloride USP equivalent to Ciprofloxacin 250 mg.
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Ciprofloxacin is indicated for the following infections: Urinary tract infections, Acute sinusitis, Lower respiratory tract infections, Skin and skin structure infections, Infectious diarrhea, Typhoid fever (Enteric fever), Bone and joint infections, Acute uncomplicated cystitis in females, Chronic bacterial prostatitis, Uncomplicated cervical and urethral gonorrhea etc.
Adults:
<table>
<thead>
<tr>
<th>Infection Type or Severity</th>
<th>Unit Dose</th>
<th>Usual Durations</th>
</tr>
</thead>
<tbody>
<tr>
<td>Acute uncomplicated urinary tract infections</td>
<td>100 mg or 250 mg b.i.d.</td>
<td>3 days</td>
</tr>
<tr>
<td>Mild/Moderate urinary tract infections</td>
<td>250 mg b.i.d.</td>
<td>7 to 14 days</td>
</tr>
<tr>
<td>Severe/Complicated urinary tract infections</td>
<td>500 mg b.i.d.</td>
<td>7 to 14 days</td>
</tr>
<tr>
<td>Acute sinusitis (Mild/Moderate)</td>
<td>500 mg b.i.d.</td>
<td>10 days</td>
</tr>
<tr>
<td>Lower respiratory tract infections (Mild/Moderate)</td>
<td>500 mg b.i.d.</td>
<td>7 to 14 days</td>
</tr>
<tr>
<td>Lower respiratory tract infections (Severe/Complicated)</td>
<td>750 mg b.i.d.</td>
<td>7 to 14 days</td>
</tr>
<tr>
<td>Skin and skin structure infections (Mild/Moderate)</td>
<td>500 mg b.i.d.</td>
<td>7 to 14 days</td>
</tr>
<tr>
<td>Skin and skin structure infections (Severe/Complicated)</td>
<td>750 mg b.i.d.</td>
<td>7 to 14 days</td>
</tr>
<tr>
<td>Infectious diarrhea (Mild/Moderate/Severe)</td>
<td>500 mg b.i.d.</td>
<td>5 to 7 days</td>
</tr>
<tr>
<td>Typhoid fever (Mild/Moderate)</td>
<td>500 mg b.i.d.</td>
<td>10 days</td>
</tr>
<tr>
<td>Bone and joint infections (Mild/Moderate)</td>
<td>500 mg b.i.d.</td>
<td>4 to 6 weeks</td>
</tr>
<tr>
<td>Bone and joint infections (Severe/Complicated)</td>
<td>750 mg b.i.d.</td>
<td>4 to 6 weeks</td>
</tr>
<tr>
<td>Chronic bacterial prostatitis (Mild/Moderate)</td>
<td>500 mg b.i.d.</td>
<td>28 days</td>
</tr>
<tr>
<td>Urethral & cervical gonococcal infections (Uncomplicated)</td>
<td>250 mg</td>
<td>Single dose</td>
</tr>
</tbody>
</table>
Children:
Increased plasma levels of theophylline have been observed following concurrent administration with Ciprofloxacin. Ciprofloxacinsuspension should not be administered within 4 hours of medications containing magnesium, aluminum, calcium, or iron salts as interference with absorption may occur.
Ciprofloxacin is contra-indicated in patients who have shown hypersensitivity to Ciprofloxacin or other quinolones.
Ciprofloxacin is generally well tolerated. The most frequently reported side effects are nausea, diarrhea, rash, retinal detachment, tendinitis & tendon rupture.
Ciprofloxacin is not recommended during pregnancy & lactation.
Ciprofloxacin should be used with caution in epileptics and patients with a history of CNS disorders. Crystalluria related to the use of Ciprofloxacin has been reported. Patients receiving Ciprofloxacin should be well hydrated and excessive alkalinity of the urine should be avoided