Prescription Required: Registered Medical Practitioner's prescription is required to purchase this product.

Human

Anzet

Tablet

0.5 mg + 10 mg

GENERIC NAMEFlupentixol + Melitracen

MANUFACTURED BYPopular Pharmaceuticals PLC

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Available Pack Sizes:1 Size

Purchase Option:Full Pack

Maximum Retail Price (MRP):

Quantity

৳ 45.00/ 10 x 10

(Unit: ৳ 5.00 / 1 Tablet)

16263

Composition

Anzet tablet: Each film coated tablet contains Flupentixol Hydrochloride BP equivalent to 0.5 mg Flupentixol & Melitracen Hydrochloride INN equivalent to 10 mg Melitracen.

Description

It consists of two well known and well proven compounds; Flupentixol is a neuroleptic with anxiolytic and antidepressant properties when given in small doses, and Melitracen is a bipolar thymoleptic with activating properties in low doses. In combination the compound renders a preparation with antidepressant, anxiolytic and activating properties and mutually neutralizes side effects.

Mechanism of Action:

Flupentixol acts by blocking the Dopamine (a neurotransmitter) receptors in the brain cells. Excess amount of dopamine receptors normally act to modify behavior and over-stimulation resulting in psychotic illness. Flupentixol blocks these receptors to control psychotic illness. Thus it is neuroleptic with anxiolytic and antidepressant properties.

Melitracen acts by decreasing reuptake of norepinephrine and serotonin at the synapse resulting in high concentration of these neurotransmitters at the post-synaptic end. Thus it is antidepressant.

Indications

Anxiety, depression, apathy, Psychogenic depression, Depressive neuroses, Masked depression, Psychosomatic affections accompanied by anxiety and apathy, Menopausal depressions, Dysphoria and depression in alcoholics and drug addicts.

Dosage & Administration

Adults:* Usually 2 tablets daily; morning and noon. In severe cases the morning dose may be increased to 2 tablets. Elderly patients: 1 tablet in the morning. Maintenance dose: Usually 1 tablet in the morning. In case of insomnia or severe restlessness additional treatment with a sedative in the acute phase is recommended. *Children:* Not recommended.

*Prescription only*

Interaction

Flupentixol and Melitracen may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.

Contraindications

The immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction, untreated narrow angle glaucoma, acute alcohol, barbiturate and opiate intoxication. Flupentixol-Melitracen should not be given to patients who have received a MAO-inhibitor within two weeks. Not recommended for excitable or overactive patient since its activating effect may lead to exaggeration of these characteristics.

Side Effects

In the recommended doses side effects are rare.

These could be transient restlessness and insomnia.

Precautions & Warnings

If previously the patient has been treated with tranquilizers with sedative effects these should be withdrawn gradually. *Use in Pregnancy and Lactation:* Flupentixol - Melitracen should preferably not be given during pregnancy and lactation.

Overdosage:

Symptoms:* In cases of overdosage the symptoms of intoxication by Melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal symptoms due to Flupentixol occur. *Treatment:* It should be symptomatic and supportive. Gastric lavage should be carried out as soon as possible and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be treated with Diazepam and extrapyramidal symptoms with biperiden.

Storage Conditions

Store at below 30°C in a dry place protected from light. Keep out of reach of children.

Anzet • 10 x 10

৳ 45.00