Ampol 500 Tablet: Each tablet contains Paracetamol BP 500 mg.
Ampol which is one of the safest and most widely used analgesic and antipyretic. Paracetamol produces analgesic action by elevation of the pain threshold and antipyresis through action on the hypothalamic heat regulating center. Ampol is rapidly and completely absorbed from the GIT following oral administration. The mean half-life of absorption from the upper small intestine is only 7 minutes. The drug is extensively metabolized in the liver and it has a plasma half-life of 1.5 to 3.0 hours. Ampol is not bound to plasma proteins to any extent.
Adults: 1-2 tablets, 3-4 times daily.
With medicine: Cholestyramine: Cholestyramine reduces absorption of paracetamol. Metoclopramide & Domperidone: Metoclopramide & Domperidone accelerate absorption of paracetamol.
With food and others: Alcohol should not take with paracetamol, alcohol combined with paracetamol can cause liver damage.
Paracetamol is contraindicated for patients with known hypersensitivity to the drug and patients with severe impaired renal and hepatic disease.
Common: Side effects of paracetamol are usually mild, though hematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported.
Rare: Pancreatitis, skin rashes, other allergic reactions, hypotension and tachycardia occur occasionally.
Overdose
Symptoms of overdose include pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12-48 hours after ingestion.
Pregnant or nursing mother should consult with a physician before using this product.
Paracetamol should be given with caution to patients with impaired kidney or liver function. Paracetamol should be given with care to patients taking other drugs that affect the liver.