Amotrex 200mg Tablets: Each tablet contains Metronidazole BP 200mg.
Amotrex 400mg Tablets: Each tablet contains Metronidazole BP 400mg.
Amotrex DS 800mg Tablets: Each tablet contains Metronidazole BP 800mg.
Amotrex Suspension: Each 5ml contains Metronidazole 200mg as Benzoyl BP.
Amotrex ® is active against a wide range of pathogenic microorganisms notably Bacteroides, Fusobacteria, Clostridia, Eubacteria and Anaerobic cocci. Amotrex¨ is also active against Trichomonas, Entamoeba hystolytica, Giardia lamblia and Balantidium coli.
Uses Amotrex ® is active against a wide range of pathogenic microorganisms notably Bacteroides, Fusobacteria, Clostridia, Eubacteria and Anaerobic cocci. Amotrex¨ is also active against Trichomonas, Entamoeba hystolytica, Giardia lamblia and Balantidium coli. It is indicated in: 1.The prevention of post-operative infections due to anaerobic bacteria, particularly species of bacteroides and anaerobic streptococci. 2.The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis and post-operative woundinfections from which susceptible pathogenic anaerobes have been isolated. 3.Urogenital trichomoniasis in the female (trichomonal vaginitis) and in the male. 4.Bacterial vaginitis. 5.All forms of amoebiasis (intestinal or extra intestinal diseases and that of symptomless cyst passers). 6.Giardiasis. 7.Acute ulcerative gingivitis. 8.Anaerobically infected leg ulcers and pressure sores. 9.Acute dental infections (eg acute pericoronitis and acute apical infections). Metronidazole is rapidly and almost completely absorbed on administration. Peak plasma concentration occurs after 20 min to 3 hours. The elimination half-life of Metronidazole is 7-8 hours. Metronidazole can be used in chronic ranal failure; it is rapidly removed by dialysis. Metronidazole is excreted in milk but the intake of a suckling infant of a mother receiving normal dosage would be considerably less than the therapeutic dosage for infants.
No Data
Route: Oral (tablets swallowed whole with water during/after meals; suspension 1 hour before meals)
Adults:
Children:
7.5 mg/kg 8-hourly.
Elderly:
Caution advised with high dosage regimens.
Alcohol causes disulfiram-like reactions (flushing, nausea, tachycardia); enhances anticoagulant effect of warfarin (monitor prothrombin time/INR); lithium clearance is reduced leading to lithium toxicity; phenytoin and phenobarbital accelerate metronidazole elimination; cimetidine prolongs clearance.
Hypersensitivity to metronidazole, other nitroimidazole derivatives, or any components of the formulation.
Less Common: Unpleasant taste, furred tongue, nausea, vomiting, GI disturbances, urticaria, angioedema. Rare: Drowsiness, dizziness, headache, ataxia, rash, pruritus, dark urine, peripheral neuropathy, seizures, transient leukopenia, anaphylaxis.
Overdose
There is no specific treatment for gross overdosage of Amotrex ® .
Category B (Contraindicated in 1st trimester). Avoid during first trimester; use in 2nd/3rd trimesters only if clearly needed; avoid high-dose regimens. Lactation: Excreted in breast milk; discontinue nursing or discontinue drug.
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.