Each ml contains:
Active substance: Alcaftadine INN 2.5 mg.
Preservative: Benzalkonium Chloride 0.05 mg.
Alcadin ophthalmic solution containing Alcaftadine for topical administration to the eyes.
Pharmacology:
Alcaftadine is a potent histamine H₁, H₂ & H₄ receptor antagonist with anti-inflammatory properties. The activation of H₁ receptor causes itching & H₄ receptor causes itching & inflammation. Histamine binding with H₁ & H₂ receptor causes redness and swelling.
Alcaftadine also inhibit the release of histamine from mast cell through limit the entry of Ca⁺⁺ across the membrane as a result prevent degranulation.
Alcaftadine also stabilize tight junction protein (zonula occludin) of conjunctival epithelium that normally becomes disorganized following allergen exposure so that decreased chemotaxis and inhibition of eosinophil activation has also been demonstrated.
Alcadin eye drops indicated for the treatment of signs and symptoms (itchy, watery, red and swollen eyes and/or eyelids) of allergic conjunctivitis including vernal keratoconjunctivitis, vernal keratitis, blepharitis, blepharoconjunctivitis and giant papillary conjunctivitis.
The recommended dose of Alcadin eye drops is 1 drop in the affected eye(s) once a day.
*Prescription only*
A. Contamination of Tip and Solution:
To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use.
B. Contact Lens Use:
Remove contact lenses prior to instillation of Alcaftadine. Lenses may be reinserted after 10 minutes following administration of Alcaftadine.
Store at below 30°C in a dry place protected from light and freezing. Do not touch dropper tip to any surface. Do not use after one month of first opening of the bottle.