Alarup Tablet: Each tablet contains Rupatadine Fumarate INN equivalent to 10 mg Rupatadine.
Rupatadine is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H1 receptor antagonist activity. It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies. Rupatadine possesses anti-allergic properties such as the inhibition of degranulation of mast cells induced by immunological and non-immunological stimuli, and inhibition of the release of cytokines, particularly of the TNF (Tumor Necrosis Fator) in human mast cells and monocytes.
Rupatadine is indicated for the symptomatic treatment of.
Adults and adolescents (over 12 years of age) - The recommended dose is 10 mg (one tablet) once a day, with or without food.
Elderly (above 65 years) - Rupatadine should be used with caution in elderly. No information is available that indicates the requirement of any dose adjustment for this group of patients.
*Prescription only*
Use with caution when administered concomitantly with inhibitors of the isozyme CYP3A4 e.g. Ketoconazole or Erythromycin. Psychomotor performance can be impaired when taken with alcohol. As with other antihistamines, interactions with CNS depressants cannot be excluded. Asymptomatic CPK (Creatinine Phospho Kinase) increases have been uncommonly reported. The risk of interactions with statins, is unknown; therefore, Rupatadine should be used with caution when it is coadministered with statins.
Data on a limited number exposed pregnancies indicate no adverse effects of Rupatadine on pregnancy or on the health of the foetus/newborn child. To date, no other relevant epidemiological data are available. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development. Caution should be exercised when prescribing Rupatadine to pregnant women. Rupatadine is excreted in animal milk. It is unknown whether Rupatadine is excreted into breast milk. Due to the lack of human data, caution should be exercised when prescribing Rupatadine to lactating mother.
An accidental consumption of very high dose should be treated symptomatically together with the necessary supportive measures.
Administration of a dose of 10 mg daily of Rupatadine has not shown significant effects on the function of the central nervous system as seen in specific studies done for psychomotor function. Nevertheless, the patient should take precaution in driving or managing machines.
Store at below 30°C in a dry place protected from light. Keep out of reach of children.