Each capsule contains Tetracycline Hydrochloride BP 500 mg.
A-Tetra (Tetracycline Hydrochloride) is a semisynthetic Tetracycline produced from Chlortetracycline. It is an antibiotic isolated from *Streptomyces aureofaciens*. It is a broad spectrum antibiotic which is active against a wide range of Gram-negative and Gram-positive bacteria. Tetracycline has its main mechanism of action on protein synthesis and an energy-dependent active transport system pumps the drug through the inner cytoplasmic membrane of the bacteria. Once inside the bacterial cell, Tetracycline inhibits protein synthesis by binding specifically to 30S ribosome. The drug appears to prevent access of aminoacyl tRNA to the acceptor site on the mRNA ribosome complex. This prevents the addition of amino acid to the growing peptide chain.
When Penicillin is contraindicated, the Tetracyclines are alternative drugs in the treatment of infection.
A-Tetra (Tetracycline Hydrochloride) is also used in combination regimens to gastric and duodenal ulcer cused by *H.pylori*.
The usual daily dose for adults is 2-4 capsules (1-2 grams) divided in two or four equal doses, depending on the severity of the infection. Capsule should be taken one hour before or two hours after meals with plenty of water.
OR AS DIRECTED BY THE PHYSICIAN.
It has been reported that Tetracycline in combination with Methoxyflurane have resulted in nephrotoxicity. Milk and milk products, as well as antacids containing calcium, aluminium and magnesium impair the absorption of Tetracycline and resulting decreased serum levels. Inhibition of the antimicrobial activity of Penicillin when used in combination with Tetracycline.
Care should be taken if tetracycline is given to patients with impaired liver function. Potential hepatotoxic drugs including Erythromycin, Chloramphenicol, Isoniazid, Sulfonamide etc. should not be given concomitantly. The risk of nephrotoxicity may be increased if given with Methoxyflurane or other potentially nephrotoxic medication. Care is advisable in patients with Myasthenia gravis, who may be at risk of neuromuscular blockade.
The use of Tetracycline Hydrochloride during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of the teeth.
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.